Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin

Susceptibility to metronidazole and vancomycin, drugs of choice for Clostridium difficile infection, of 15 C. difficile isolates from 6 healthy Asian elephants was determined. All of the isolates belonged to only 1 ribotype pattern and carried both toxin A and B genes. The Minimal inhibitory concent...

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Main Authors:	Nattawooti Sthitmatee, Thanya Warinrak, Waroot Wongkalasin
Format:	Journal
Published:	2018
Subjects:	Veterinary
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882582262&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53011
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-53011
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spelling	th-cmuir.6653943832-530112018-09-04T09:38:10Z Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin Nattawooti Sthitmatee Thanya Warinrak Waroot Wongkalasin Veterinary Susceptibility to metronidazole and vancomycin, drugs of choice for Clostridium difficile infection, of 15 C. difficile isolates from 6 healthy Asian elephants was determined. All of the isolates belonged to only 1 ribotype pattern and carried both toxin A and B genes. The Minimal inhibitory concentration range of metronidazole and vancomycin, drugs of choice for treatment of C. difficile infection, was 0.125-4.0 μg/ml and 0.125-2.0 μg/ml, respectively. Moreover, MIC50 and MIC90 for metronidazole were 0.75 and 1.5 μg/ml while vancomycin was 1.0 and 2.0 μg/ml. There was no evidence of resistance to these antimicrobials. These results might be a preliminary data for further study of animal C. difficile. 2018-09-04T09:38:10Z 2018-09-04T09:38:10Z 2013-08-27 Journal 01256491 2-s2.0-84882582262 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882582262&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53011
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Veterinary
spellingShingle	Veterinary Nattawooti Sthitmatee Thanya Warinrak Waroot Wongkalasin Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
description	Susceptibility to metronidazole and vancomycin, drugs of choice for Clostridium difficile infection, of 15 C. difficile isolates from 6 healthy Asian elephants was determined. All of the isolates belonged to only 1 ribotype pattern and carried both toxin A and B genes. The Minimal inhibitory concentration range of metronidazole and vancomycin, drugs of choice for treatment of C. difficile infection, was 0.125-4.0 μg/ml and 0.125-2.0 μg/ml, respectively. Moreover, MIC50 and MIC90 for metronidazole were 0.75 and 1.5 μg/ml while vancomycin was 1.0 and 2.0 μg/ml. There was no evidence of resistance to these antimicrobials. These results might be a preliminary data for further study of animal C. difficile.
format	Journal
author	Nattawooti Sthitmatee Thanya Warinrak Waroot Wongkalasin
author_facet	Nattawooti Sthitmatee Thanya Warinrak Waroot Wongkalasin
author_sort	Nattawooti Sthitmatee
title	Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
title_short	Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
title_full	Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
title_fullStr	Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
title_full_unstemmed	Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
title_sort	susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882582262&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53011
_version_	1681424056069390336

Susceptibility of clostridium difficile isolated from healthy captive asian elephants to metronidazole and vancomycin

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