Host-derived nitrate boosts growth of E. coli in the inflamed gut
Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms b...
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th-cmuir.6653943832-530442018-09-04T09:38:37Z Host-derived nitrate boosts growth of E. coli in the inflamed gut Sebastian E. Winter Maria G. Winter Mariana N. Xavier Parameth Thiennimitr Victor Poon A. Marijke Keestra Richard C. Laughlin Gabriel Gomez Jing Wu Sara D. Lawhon Ina E. Popova Sanjai J. Parikh L. Garry Adams Renée M. Tsolis Valley J. Stewart Andreas J. Bäumler Multidisciplinary Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient in inducible nitric oxide synthase did not support the growth of E. coli by nitrate respiration, suggesting that the nitrate generated during inflammation was host-derived. Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration. 2018-09-04T09:38:37Z 2018-09-04T09:38:37Z 2013-02-08 Journal 10959203 00368075 2-s2.0-84873513423 10.1126/science.1232467 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873513423&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53044 |
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Multidisciplinary Sebastian E. Winter Maria G. Winter Mariana N. Xavier Parameth Thiennimitr Victor Poon A. Marijke Keestra Richard C. Laughlin Gabriel Gomez Jing Wu Sara D. Lawhon Ina E. Popova Sanjai J. Parikh L. Garry Adams Renée M. Tsolis Valley J. Stewart Andreas J. Bäumler Host-derived nitrate boosts growth of E. coli in the inflamed gut |
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Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic bacteria, whereas the relative abundance of facultative anaerobic Enterobacteriaceae increases. The mechanisms by which the host response shapes the microbial community structure, however, remain unknown. We show that nitrate generated as a by-product of the inflammatory response conferred a growth advantage to the commensal bacterium Escherichia coli in the large intestine of mice. Mice deficient in inducible nitric oxide synthase did not support the growth of E. coli by nitrate respiration, suggesting that the nitrate generated during inflammation was host-derived. Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration. |
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Journal |
author |
Sebastian E. Winter Maria G. Winter Mariana N. Xavier Parameth Thiennimitr Victor Poon A. Marijke Keestra Richard C. Laughlin Gabriel Gomez Jing Wu Sara D. Lawhon Ina E. Popova Sanjai J. Parikh L. Garry Adams Renée M. Tsolis Valley J. Stewart Andreas J. Bäumler |
author_facet |
Sebastian E. Winter Maria G. Winter Mariana N. Xavier Parameth Thiennimitr Victor Poon A. Marijke Keestra Richard C. Laughlin Gabriel Gomez Jing Wu Sara D. Lawhon Ina E. Popova Sanjai J. Parikh L. Garry Adams Renée M. Tsolis Valley J. Stewart Andreas J. Bäumler |
author_sort |
Sebastian E. Winter |
title |
Host-derived nitrate boosts growth of E. coli in the inflamed gut |
title_short |
Host-derived nitrate boosts growth of E. coli in the inflamed gut |
title_full |
Host-derived nitrate boosts growth of E. coli in the inflamed gut |
title_fullStr |
Host-derived nitrate boosts growth of E. coli in the inflamed gut |
title_full_unstemmed |
Host-derived nitrate boosts growth of E. coli in the inflamed gut |
title_sort |
host-derived nitrate boosts growth of e. coli in the inflamed gut |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873513423&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53044 |
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1681424062109188096 |