Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity

• Main Authors: Jirapas Sripetchwandee, Noppamas Pipatpiboon, Nipon Chattipakorn, Siriporn Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896460432&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53097
• Institution: Chiang Mai University

Background: Excessive iron accumulation leads to iron toxicity in the brain; however the underlying mechanism is unclear. We investigated the effects of iron overload induced by high iron-diet consumption on brain mitochondrial function, brain synaptic plasticity and learning and memory. Iron chelat...