Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

• Main Authors: Xufang Deng, Sarah E. St John, Heather L. Osswald, Amornrat O'Brien, Bridget S. Banach, Katrina Sleeman, Arun K. Ghosh, Andrew D. Mesecar, Susan C. Baker
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907442809&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53168
• Institution: Chiang Mai University

© 2014, American Society for Microbiology. Viral protease inhibitors are remarkably effective at blocking the replication of viruses such as human immunodeficiency virus and hepatitis C virus, but they inevitably lead to the selection of inhibitor-resistant mutants, which may contribute to ongoing d...