Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin

In this study, hydroxypropyl methylcellulose (HPMC, Methocel™ E4M) was chosen in 0.3% and 0.4% w/v concentrations at pH 7.1 as an ocular drug delivery vehicle for vancomycin and its in vitro characteristics and stability determined. The viscosity, osmolality, clarity, pH and contamination of each of...

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Main Author: Anutra Khangtragool
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53196
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-531962018-09-04T10:01:14Z Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin Anutra Khangtragool Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy In this study, hydroxypropyl methylcellulose (HPMC, Methocel™ E4M) was chosen in 0.3% and 0.4% w/v concentrations at pH 7.1 as an ocular drug delivery vehicle for vancomycin and its in vitro characteristics and stability determined. The viscosity, osmolality, clarity, pH and contamination of each of the formulations were determined. From stability assessments, Methocel™ E4M 0.3% and 0.4% w/v pH 7.1 could be stored at 2-8°C and 30°C for 360 days. Osmolalities and pH were acceptable for use in the eyes. No contamination was found in both 0.3% and 0.4% w/v Methocel™ E4M pH 7.1. All solutions remained clear throughout the study. The kinematic viscosity of Methocel™ E4M 0.3% w/v relative to artificial tears indicated that it was suitable for the ocular drug delivery of vancomycin 50 mg/ml. 2018-09-04T09:45:07Z 2018-09-04T09:45:07Z 2014-02-11 Journal 01252526 2-s2.0-84893468495 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84893468495&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53196
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Materials Science
Mathematics
Physics and Astronomy
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Materials Science
Mathematics
Physics and Astronomy
Anutra Khangtragool
Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
description In this study, hydroxypropyl methylcellulose (HPMC, Methocel™ E4M) was chosen in 0.3% and 0.4% w/v concentrations at pH 7.1 as an ocular drug delivery vehicle for vancomycin and its in vitro characteristics and stability determined. The viscosity, osmolality, clarity, pH and contamination of each of the formulations were determined. From stability assessments, Methocel™ E4M 0.3% and 0.4% w/v pH 7.1 could be stored at 2-8°C and 30°C for 360 days. Osmolalities and pH were acceptable for use in the eyes. No contamination was found in both 0.3% and 0.4% w/v Methocel™ E4M pH 7.1. All solutions remained clear throughout the study. The kinematic viscosity of Methocel™ E4M 0.3% w/v relative to artificial tears indicated that it was suitable for the ocular drug delivery of vancomycin 50 mg/ml.
format Journal
author Anutra Khangtragool
author_facet Anutra Khangtragool
author_sort Anutra Khangtragool
title Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
title_short Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
title_full Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
title_fullStr Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
title_full_unstemmed Methocel E4M: Preparation and properties as a vehicle for the ocular drug delivery of vancomycin
title_sort methocel e4m: preparation and properties as a vehicle for the ocular drug delivery of vancomycin
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84893468495&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53196
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