Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand

Background: Northern Thailand is a region with a high cervical cancer incidence. Combined high-risk HPV (hrHPV) DNA testing and cytology (co-testing) has increasingly gained acceptance for cervical cancer screening. However, to our knowledge, data from a population-based screening using co-testing h...

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Main Authors: Sumalee Siriaunkgul, Jongkolnee Settakorn, Kornkanok Sukpan, Jatupol Srisomboon, Prapaporn Suprasert, Nongyao Kasatpibal, Surapan Khunamornpong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53219
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spelling th-cmuir.6653943832-532192018-09-04T09:57:57Z Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand Sumalee Siriaunkgul Jongkolnee Settakorn Kornkanok Sukpan Jatupol Srisomboon Prapaporn Suprasert Nongyao Kasatpibal Surapan Khunamornpong Biochemistry, Genetics and Molecular Biology Medicine Background: Northern Thailand is a region with a high cervical cancer incidence. Combined high-risk HPV (hrHPV) DNA testing and cytology (co-testing) has increasingly gained acceptance for cervical cancer screening. However, to our knowledge, data from a population-based screening using co-testing have not been available in this region. This study therefore aimed to evaluate the performance of cytology and hrHPV test in women in northern Thailand. Materials and Methods: Cervical samples were collected for hybrid capture 2 (HC2) testing and liquid-based cytology from women aged 30 to 60 years who were residents in 3 prefectures of Chiang Mai in northern Thailand between May and September 2011. Women with positive cytology were referred to colposcopy, while women with positive for HC2 only were followed for 2 years. Results: Of 2,752 women included in this study, 3.0% were positive in both tests, 4.1% for HC2 only, and 1.3% had positive cytology only. At baseline screening, positive HC2 was observed in 70.6% among cytology-positive women compared with 4.3% among cytology-negative women. The prevalence of positive HC2 or cytology peaked in the age group 35-39 years and was lowest in the age group 55-60 years. High-grade squamous intraepithelial lesion or worse lesions (HSIL+) were histologically detected in 23.5% of women with positive baseline cytology and in 9.8% of women with positive baseline HC2 only on follow-up. All women with histologic HSIL+ had positive baseline HC2. Conclusions: The hrHPV test is superior to cytology in the early detection of high-grade cervical epithelial lesions. In this study, the prevalence of histologic HSIL+ on follow-up of women with positive hrHPV test was rather high, and these women should be kept under careful surveillance. In northern Thailand, hrHPV testing has a potential to be used as a primary screening test for cervical cancer with cytology applied as a triage test. 2018-09-04T09:45:23Z 2018-09-04T09:45:23Z 2014-01-01 Journal 15137368 2-s2.0-84923062720 10.7314/APJCP.2014.15.16.6837 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84923062720&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53219
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Sumalee Siriaunkgul
Jongkolnee Settakorn
Kornkanok Sukpan
Jatupol Srisomboon
Prapaporn Suprasert
Nongyao Kasatpibal
Surapan Khunamornpong
Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
description Background: Northern Thailand is a region with a high cervical cancer incidence. Combined high-risk HPV (hrHPV) DNA testing and cytology (co-testing) has increasingly gained acceptance for cervical cancer screening. However, to our knowledge, data from a population-based screening using co-testing have not been available in this region. This study therefore aimed to evaluate the performance of cytology and hrHPV test in women in northern Thailand. Materials and Methods: Cervical samples were collected for hybrid capture 2 (HC2) testing and liquid-based cytology from women aged 30 to 60 years who were residents in 3 prefectures of Chiang Mai in northern Thailand between May and September 2011. Women with positive cytology were referred to colposcopy, while women with positive for HC2 only were followed for 2 years. Results: Of 2,752 women included in this study, 3.0% were positive in both tests, 4.1% for HC2 only, and 1.3% had positive cytology only. At baseline screening, positive HC2 was observed in 70.6% among cytology-positive women compared with 4.3% among cytology-negative women. The prevalence of positive HC2 or cytology peaked in the age group 35-39 years and was lowest in the age group 55-60 years. High-grade squamous intraepithelial lesion or worse lesions (HSIL+) were histologically detected in 23.5% of women with positive baseline cytology and in 9.8% of women with positive baseline HC2 only on follow-up. All women with histologic HSIL+ had positive baseline HC2. Conclusions: The hrHPV test is superior to cytology in the early detection of high-grade cervical epithelial lesions. In this study, the prevalence of histologic HSIL+ on follow-up of women with positive hrHPV test was rather high, and these women should be kept under careful surveillance. In northern Thailand, hrHPV testing has a potential to be used as a primary screening test for cervical cancer with cytology applied as a triage test.
format Journal
author Sumalee Siriaunkgul
Jongkolnee Settakorn
Kornkanok Sukpan
Jatupol Srisomboon
Prapaporn Suprasert
Nongyao Kasatpibal
Surapan Khunamornpong
author_facet Sumalee Siriaunkgul
Jongkolnee Settakorn
Kornkanok Sukpan
Jatupol Srisomboon
Prapaporn Suprasert
Nongyao Kasatpibal
Surapan Khunamornpong
author_sort Sumalee Siriaunkgul
title Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
title_short Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
title_full Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
title_fullStr Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
title_full_unstemmed Population-based cervical cancer screening using highrisk HPV DNA test and liquid-based cytology in Northern Thailand
title_sort population-based cervical cancer screening using highrisk hpv dna test and liquid-based cytology in northern thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84923062720&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53219
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