Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand

Background: There have been no reports for the frequency of Hb Q-Thailand [α 74(EF3)Asp→His, GAC > CAC] and its combinations either with other forms of thalassemia or hemoglobinopathies in Northern Thailand. The aims of this study were to search for Hb Q-Thailand and its combinations in Northern...

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Main Authors: Sitthichai Panyasai, Sakorn Pornprasert
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53249
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spelling th-cmuir.6653943832-532492018-09-04T09:45:51Z Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand Sitthichai Panyasai Sakorn Pornprasert Biochemistry, Genetics and Molecular Biology Background: There have been no reports for the frequency of Hb Q-Thailand [α 74(EF3)Asp→His, GAC > CAC] and its combinations either with other forms of thalassemia or hemoglobinopathies in Northern Thailand. The aims of this study were to search for Hb Q-Thailand and its combinations in Northern Thai population and to analyze fractions of hemoglobin in Hb Q-Thailand and its combinations on high performance liquid chromatography (HPLC) chromatograms and/or capillary electrophoresis (CE) electrophoregrams. Methods: Blood samples from public and private hospitals in 7 northern provinces of Thailand were analyzed for thalassemia and hemoglobinopathy diagnoses using HPLC and/or CE and DNA analysis techniques at the Thalassemia Laboratory, Associated Medical Sciences Clinical Service Center, Chiang Mai, Thailand. Results: Hb Q-Thailand was found in 13 of 13,596 (0.10%) samples; 6 were heterozygous Hb Q-Thailand, 4 were compound Hb Q-Thailand/α-thalassemia-1 Southeast Asian (SEA) type deletion and 3 with combinations of Hb Q-Thailand/β0- thalassemia, Hb Q-Thailand/Hb E and Hb Q-Thailand/Hb E/α-thalassemia-1 SEA type deletion. The fractions of hemoglobin on HPLC chromatograms and CE electrophoregrams were observed based on types of combinations. Conclusions: Hb Q-Thailand and its combinations could be found in northern Thai population with the frequency of 0.10%. Thus, the better understanding of HPLC chromatogram and/or CE electrophoregram patterns of Hb Q-Thailand and its combination is essential for diagnosis and genetic counseling of thalassemia and hemoglobinopathies in this area. 2018-09-04T09:45:51Z 2018-09-04T09:45:51Z 2014-01-01 Journal 14336510 2-s2.0-84905009572 10.7754/Clin.Lab.2013.130513 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905009572&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53249
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Sitthichai Panyasai
Sakorn Pornprasert
Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
description Background: There have been no reports for the frequency of Hb Q-Thailand [α 74(EF3)Asp→His, GAC > CAC] and its combinations either with other forms of thalassemia or hemoglobinopathies in Northern Thailand. The aims of this study were to search for Hb Q-Thailand and its combinations in Northern Thai population and to analyze fractions of hemoglobin in Hb Q-Thailand and its combinations on high performance liquid chromatography (HPLC) chromatograms and/or capillary electrophoresis (CE) electrophoregrams. Methods: Blood samples from public and private hospitals in 7 northern provinces of Thailand were analyzed for thalassemia and hemoglobinopathy diagnoses using HPLC and/or CE and DNA analysis techniques at the Thalassemia Laboratory, Associated Medical Sciences Clinical Service Center, Chiang Mai, Thailand. Results: Hb Q-Thailand was found in 13 of 13,596 (0.10%) samples; 6 were heterozygous Hb Q-Thailand, 4 were compound Hb Q-Thailand/α-thalassemia-1 Southeast Asian (SEA) type deletion and 3 with combinations of Hb Q-Thailand/β0- thalassemia, Hb Q-Thailand/Hb E and Hb Q-Thailand/Hb E/α-thalassemia-1 SEA type deletion. The fractions of hemoglobin on HPLC chromatograms and CE electrophoregrams were observed based on types of combinations. Conclusions: Hb Q-Thailand and its combinations could be found in northern Thai population with the frequency of 0.10%. Thus, the better understanding of HPLC chromatogram and/or CE electrophoregram patterns of Hb Q-Thailand and its combination is essential for diagnosis and genetic counseling of thalassemia and hemoglobinopathies in this area.
format Journal
author Sitthichai Panyasai
Sakorn Pornprasert
author_facet Sitthichai Panyasai
Sakorn Pornprasert
author_sort Sitthichai Panyasai
title Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
title_short Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
title_full Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
title_fullStr Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
title_full_unstemmed Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in Northern Thailand
title_sort hemoglobin q-thailand and its combinations with other forms of thalassemia or hemoglobinopathies in northern thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905009572&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53249
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