Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis

A subject with Hb E (HBB: c.79G > A) trait is asymptomatic and can become a blood donor. However, a blood transfusion from a Hb E trait donor can affect β-thalassemia (β-thal) diagnosis. Blood samples from three Thai women were sent to the Associated Medical Sciences (AMS) Clinical Service Center...

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Main Authors: Sakorn Pornprasert, Kanokwan Jaiping
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53255
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-532552018-09-04T09:58:33Z Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis Sakorn Pornprasert Kanokwan Jaiping Biochemistry, Genetics and Molecular Biology Medicine A subject with Hb E (HBB: c.79G > A) trait is asymptomatic and can become a blood donor. However, a blood transfusion from a Hb E trait donor can affect β-thalassemia (β-thal) diagnosis. Blood samples from three Thai women were sent to the Associated Medical Sciences (AMS) Clinical Service Center, Chiang Mai, Thailand, for thalassemia diagnosis. Their Hb A2 levels, analyzed by high performance liquid chromatography (HPLC), were higher than 4.0%, thus they were diagnosed to have β-thal. However, elevated Hb A2 levels in these patients were not certain because the Hb A2 levels analyzed at the initial hospitalization and follow-up were controversial. In addition, there were some cases shown to have controversy between the increased Hb A2 level and red cell indices. The blood transfusion history was confirmed and hemoglobin (Hb) analysis was reanalyzed by capillary electrophoresis (CE). On the CE electrophoregram, Hb A2 levels were observed to be normal and Hb E peaks were present. Therefore, to rule out misdiagnosis and unnecessary genetic counseling, Hb analysis should be performed on the recipient prior to blood transfusions. Moreover, CE has a high efficiency to prevent the misinterpretation of Hb analysis in patients who receive blood transfusions from a donor carrying Hb E. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. 2018-09-04T09:45:56Z 2018-09-04T09:45:56Z 2014-01-01 Journal 1532432X 03630269 2-s2.0-84904366276 10.3109/03630269.2014.926913 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904366276&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53255
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Sakorn Pornprasert
Kanokwan Jaiping
Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
description A subject with Hb E (HBB: c.79G > A) trait is asymptomatic and can become a blood donor. However, a blood transfusion from a Hb E trait donor can affect β-thalassemia (β-thal) diagnosis. Blood samples from three Thai women were sent to the Associated Medical Sciences (AMS) Clinical Service Center, Chiang Mai, Thailand, for thalassemia diagnosis. Their Hb A2 levels, analyzed by high performance liquid chromatography (HPLC), were higher than 4.0%, thus they were diagnosed to have β-thal. However, elevated Hb A2 levels in these patients were not certain because the Hb A2 levels analyzed at the initial hospitalization and follow-up were controversial. In addition, there were some cases shown to have controversy between the increased Hb A2 level and red cell indices. The blood transfusion history was confirmed and hemoglobin (Hb) analysis was reanalyzed by capillary electrophoresis (CE). On the CE electrophoregram, Hb A2 levels were observed to be normal and Hb E peaks were present. Therefore, to rule out misdiagnosis and unnecessary genetic counseling, Hb analysis should be performed on the recipient prior to blood transfusions. Moreover, CE has a high efficiency to prevent the misinterpretation of Hb analysis in patients who receive blood transfusions from a donor carrying Hb E. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.
format Journal
author Sakorn Pornprasert
Kanokwan Jaiping
author_facet Sakorn Pornprasert
Kanokwan Jaiping
author_sort Sakorn Pornprasert
title Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
title_short Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
title_full Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
title_fullStr Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
title_full_unstemmed Blood transfusion from a Hb e trait donor can affect β-thalassemia diagnosis
title_sort blood transfusion from a hb e trait donor can affect β-thalassemia diagnosis
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904366276&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53255
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