Root dentin anomaly and a PLG mutation

© 2014 Elsevier Masson SAS. We report a Thai girl affected with plasminogen deficiency, Type I. Ligneous conjunctivitis was first observed when she was one-month-old. The newly recognized findings include tapered incisor roots as a result of thin root dentin, generalized short tooth roots, and mandi...

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Main Authors:	Napaporn Tananuvat, Pimlak Charoenkwan, Atsushi Ohazama, James R. Ketuda Cairns, Massupa Kaewgahya, Piranit Nik Kantaputra
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Medicine
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84918834387&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53295
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-53295
record_format	dspace
spelling	th-cmuir.6653943832-532952018-09-04T09:59:20Z Root dentin anomaly and a PLG mutation Napaporn Tananuvat Pimlak Charoenkwan Atsushi Ohazama James R. Ketuda Cairns Massupa Kaewgahya Piranit Nik Kantaputra Biochemistry, Genetics and Molecular Biology Medicine © 2014 Elsevier Masson SAS. We report a Thai girl affected with plasminogen deficiency, Type I. Ligneous conjunctivitis was first observed when she was one-month-old. The newly recognized findings include tapered incisor roots as a result of thin root dentin, generalized short tooth roots, and mandibular prognathism. Mutation analysis of PLG demonstrated homozygous c.1193G>A missense mutation. The parents were heterozygous for c.1193G>A mutation. The c.1193G>A mutation is novel and predicted to cause amino acid substitution p.Cys398Tyr. Thin root dentin in the patient who was affected with PLG mutation and immunolocalization of Plg during early root development in mice imply the role of plasminogen in root dentin formation. 2018-09-04T09:46:31Z 2018-09-04T09:46:31Z 2014-01-01 Journal 18780849 17697212 2-s2.0-84918834387 10.1016/j.ejmg.2014.09.006 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84918834387&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53295
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Medicine
spellingShingle	Biochemistry, Genetics and Molecular Biology Medicine Napaporn Tananuvat Pimlak Charoenkwan Atsushi Ohazama James R. Ketuda Cairns Massupa Kaewgahya Piranit Nik Kantaputra Root dentin anomaly and a PLG mutation
description	© 2014 Elsevier Masson SAS. We report a Thai girl affected with plasminogen deficiency, Type I. Ligneous conjunctivitis was first observed when she was one-month-old. The newly recognized findings include tapered incisor roots as a result of thin root dentin, generalized short tooth roots, and mandibular prognathism. Mutation analysis of PLG demonstrated homozygous c.1193G>A missense mutation. The parents were heterozygous for c.1193G>A mutation. The c.1193G>A mutation is novel and predicted to cause amino acid substitution p.Cys398Tyr. Thin root dentin in the patient who was affected with PLG mutation and immunolocalization of Plg during early root development in mice imply the role of plasminogen in root dentin formation.
format	Journal
author	Napaporn Tananuvat Pimlak Charoenkwan Atsushi Ohazama James R. Ketuda Cairns Massupa Kaewgahya Piranit Nik Kantaputra
author_facet	Napaporn Tananuvat Pimlak Charoenkwan Atsushi Ohazama James R. Ketuda Cairns Massupa Kaewgahya Piranit Nik Kantaputra
author_sort	Napaporn Tananuvat
title	Root dentin anomaly and a PLG mutation
title_short	Root dentin anomaly and a PLG mutation
title_full	Root dentin anomaly and a PLG mutation
title_fullStr	Root dentin anomaly and a PLG mutation
title_full_unstemmed	Root dentin anomaly and a PLG mutation
title_sort	root dentin anomaly and a plg mutation
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84918834387&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53295
_version_	1681424108667011072

Root dentin anomaly and a PLG mutation

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