Novel application of polioviral capsid: Development of a potent and prolonged oral calcitonin using polioviral binding ligand and Tat peptide

• Main Authors: Jiradej Manosroi, Warangkana Lohcharoenkal, Friedrich Götz, Rolf G. Werner, Worapaka Manosroi, Aranya Manosroi
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905509678&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53364
• Institution: Chiang Mai University

Context: Poor absorption and proteolytic degradation are major obstacles of orally administered peptide drugs including calcitonin. Cell penetrating peptides (CPPs) and receptor binding ligands are interesting tools for the application in the delivery of these drugs. Objective: To investigate the en...