Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex

• Main Authors: Warachai Praditwongwan, Phimonphan Chuankhayan, Somphot Saoin, Tanchanok Wisitponchai, Vannajan Sanghiran Lee, Sawitree Nangola, Saw See Hong, Philippe Minard, Pierre Boulanger, Chun Jung Chen, Chatchai Tayapiwatana
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Computer Science; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925284821&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53368
• Institution: Chiang Mai University

Ankyrins are cellular repeat proteins, which can be genetically modified to randomize amino-acid residues located at defined positions in each repeat unit, and thus create a potential binding surface adaptable to macromolecular ligands. From a phage-display library of artificial ankyrins, we have is...