Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared...
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th-cmuir.6653943832-534972018-09-04T10:01:04Z Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin Kiattikhun Manokruang Jae Seung Lym Doo Sung Lee Engineering Materials Science Physics and Astronomy Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V. 2018-09-04T09:50:26Z 2018-09-04T09:50:26Z 2014-06-01 Journal 0167577X 2-s2.0-84897395106 10.1016/j.matlet.2014.03.052 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897395106&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53497 |
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Engineering Materials Science Physics and Astronomy Kiattikhun Manokruang Jae Seung Lym Doo Sung Lee Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
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Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V. |
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Journal |
author |
Kiattikhun Manokruang Jae Seung Lym Doo Sung Lee |
author_facet |
Kiattikhun Manokruang Jae Seung Lym Doo Sung Lee |
author_sort |
Kiattikhun Manokruang |
title |
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
title_short |
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
title_full |
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
title_fullStr |
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
title_full_unstemmed |
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
title_sort |
injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897395106&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53497 |
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