Determination of material parameter of gelatin-carboxymethylcellouse scaffold with dehydrothermal crosslinking technique using curve fitting method

• Main Authors: Nad Siroros, Nattawit Promma
• Format: Book Series
• Published: 2018
• Subjects: Engineering
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901488240&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53512
• Institution: Chiang Mai University

Biocompatible material called scaffold helps patient suffering from skin loss or skin disorder such as burn and ulcer. The scaffold allows the wound healing process to occur in suitable condition and heal faster. There are varieties of commercial scaffold available but it is also relatively expensive. This research seeking to develop new affordable scaffold using gelatin blended with carboxymethylcellouse (CMC) to strengthen the porous structure. Moreover, the strength of the scaffold by using thermal crosslinking technique is called dehydrothermal (DHT) treatment. At this stage, identification of material parameter, in this case, shear modulus is necessary. The behavior of the material is foam-like hyperelastic material. The large deformation theory has been use to derive the constitutive equation to obtain the engineering stress equation in form of Blatz-Ko hyperelastic model. The stress-strain curve obtained from compressing test. The curve fitting method was used to identify the shear modulus of the scaffold. As a result the scaffold with 80:20 gelatin-CMC ratios is dominant and shows highest shear modulus of 12.85±3.77 kPa. However, this is can be improved. Further discussion and suggestion is given at the end of the research. © (2014) Trans Tech Publications, Switzerland.