Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand

Viral gastroenteritis is a common public health problem that causes morbidity and mortality worldwide. Recently, new viruses causing gastroenteritis have been identified. Among these, Aichivirus has also been proposed as a causative agent of gastroenteritis in human. Most studies have been conducted...

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Main Authors: Wilaiporn Saikruang, Pattara Khamrin, Boonpa Suantai, Hiroshi Ushijima, Niwat Maneekarn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53616
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-536162018-09-04T09:58:32Z Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand Wilaiporn Saikruang Pattara Khamrin Boonpa Suantai Hiroshi Ushijima Niwat Maneekarn Immunology and Microbiology Medicine Viral gastroenteritis is a common public health problem that causes morbidity and mortality worldwide. Recently, new viruses causing gastroenteritis have been identified. Among these, Aichivirus has also been proposed as a causative agent of gastroenteritis in human. Most studies have been conducted in infants and children, the information in adults is limited. Therefore, the purpose of this study was to investigate the epidemiology and molecular characterization of Aichivirus in adult patients with diarrhea. A total of 332 fecal specimens collected from January to December 2008 were screened for the presence of Aichivirus by reverse transcription-PCR (RT-PCR) method. Out of 332 fecal specimens tested, Aichivirus was detected with the prevalence of 0.9% (3/332). The data indicate that the prevalence of Aichivirus in adults was as low as those reported in children in Thailand. Phylogenetic analysis of the VP1 sequence revealed that one Aichivirus belonged to genotype A, while other two Aichiviruses were genotype B. In conclusion, this study provided the molecular epidemiological data of Aichivirus circulating in adult patients with diarrhea at low prevalence and the viruses were genetically variable as both genotypes A and B were found in this population. © 2014 Wiley Periodicals, Inc. 2018-09-04T09:52:55Z 2018-09-04T09:52:55Z 2014-01-01 Journal 10969071 01466615 2-s2.0-84897959421 10.1002/jmv.23904 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897959421&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53616
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
Wilaiporn Saikruang
Pattara Khamrin
Boonpa Suantai
Hiroshi Ushijima
Niwat Maneekarn
Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
description Viral gastroenteritis is a common public health problem that causes morbidity and mortality worldwide. Recently, new viruses causing gastroenteritis have been identified. Among these, Aichivirus has also been proposed as a causative agent of gastroenteritis in human. Most studies have been conducted in infants and children, the information in adults is limited. Therefore, the purpose of this study was to investigate the epidemiology and molecular characterization of Aichivirus in adult patients with diarrhea. A total of 332 fecal specimens collected from January to December 2008 were screened for the presence of Aichivirus by reverse transcription-PCR (RT-PCR) method. Out of 332 fecal specimens tested, Aichivirus was detected with the prevalence of 0.9% (3/332). The data indicate that the prevalence of Aichivirus in adults was as low as those reported in children in Thailand. Phylogenetic analysis of the VP1 sequence revealed that one Aichivirus belonged to genotype A, while other two Aichiviruses were genotype B. In conclusion, this study provided the molecular epidemiological data of Aichivirus circulating in adult patients with diarrhea at low prevalence and the viruses were genetically variable as both genotypes A and B were found in this population. © 2014 Wiley Periodicals, Inc.
format Journal
author Wilaiporn Saikruang
Pattara Khamrin
Boonpa Suantai
Hiroshi Ushijima
Niwat Maneekarn
author_facet Wilaiporn Saikruang
Pattara Khamrin
Boonpa Suantai
Hiroshi Ushijima
Niwat Maneekarn
author_sort Wilaiporn Saikruang
title Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
title_short Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
title_full Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
title_fullStr Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
title_full_unstemmed Molecular detection and characterization of aichivirus A in adult patients with diarrhea in Thailand
title_sort molecular detection and characterization of aichivirus a in adult patients with diarrhea in thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897959421&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53616
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