Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy

Different genotypes of hepatitis C virus (HCV) are circulating in different areas of the world. In Thailand, distribution of HCV genotypes has been investigated mostly in the central area while the information in other regions is limited. This study aimed to determine the HCV genotypes circulating i...

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Main Authors: Kattareeya Kumthip, Pattranuch Chusri, Chansom Pantip, Satawat Thongsawat, Amornrat O'Brien, Kenrad E. Nelson, Niwat Maneekarn
Format: Journal
Published: 2018
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-536182018-09-04T09:58:59Z Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy Kattareeya Kumthip Pattranuch Chusri Chansom Pantip Satawat Thongsawat Amornrat O'Brien Kenrad E. Nelson Niwat Maneekarn Immunology and Microbiology Medicine Different genotypes of hepatitis C virus (HCV) are circulating in different areas of the world. In Thailand, distribution of HCV genotypes has been investigated mostly in the central area while the information in other regions is limited. This study aimed to determine the HCV genotypes circulating in chronic hepatitis C patients in Chiang Mai, Thailand and to investigate the response of different HCV genotypes to pegylated interferon (PEG-IFN) and ribavirin (RBV) treatment. Patients infected chronically with HCV were treated with PEG-IFN/RBV based on the standard regimens for each HCV genotype and followed up the patients until the end of treatment and 6 months afterward. Out of 158 patients, three major HCV genotypes and eight subtypes were identified. Genotype 3 was the most predominant at 54.5%, followed by genotypes 1 (31%) and 6 (14.5%). Among subtypes, 3a was the most prevalent subtype (45%), followed by 1b (18.4%), 1a and 6f (each at 12.6%), 3b (9.5%), and 6a, 6i, 6n (each at 0.63%). Patients with genotype 3 showed higher rate of responding to the treatment at 80.2% compared to genotypes 1 (73.5%) and 6f (65%). Additionally, patients with genotype 6f showed higher rate of relapsing (25%) compared to genotypes 1 and 3 (14.3% and 16.3%, respectively). In conclusion, this study reported multiple HCV genotypes circulated in Thai patients and the response of different HCV genotypes to PEG-IFN/RBV treatment. J. Med. Virol. 86:1360-1365, 2014. © 2014 Wiley Periodicals, Inc. 2018-09-04T09:53:02Z 2018-09-04T09:53:02Z 2014-01-01 Journal 10969071 01466615 2-s2.0-84901801479 10.1002/jmv.23962 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901801479&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53618
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
Kattareeya Kumthip
Pattranuch Chusri
Chansom Pantip
Satawat Thongsawat
Amornrat O'Brien
Kenrad E. Nelson
Niwat Maneekarn
Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
description Different genotypes of hepatitis C virus (HCV) are circulating in different areas of the world. In Thailand, distribution of HCV genotypes has been investigated mostly in the central area while the information in other regions is limited. This study aimed to determine the HCV genotypes circulating in chronic hepatitis C patients in Chiang Mai, Thailand and to investigate the response of different HCV genotypes to pegylated interferon (PEG-IFN) and ribavirin (RBV) treatment. Patients infected chronically with HCV were treated with PEG-IFN/RBV based on the standard regimens for each HCV genotype and followed up the patients until the end of treatment and 6 months afterward. Out of 158 patients, three major HCV genotypes and eight subtypes were identified. Genotype 3 was the most predominant at 54.5%, followed by genotypes 1 (31%) and 6 (14.5%). Among subtypes, 3a was the most prevalent subtype (45%), followed by 1b (18.4%), 1a and 6f (each at 12.6%), 3b (9.5%), and 6a, 6i, 6n (each at 0.63%). Patients with genotype 3 showed higher rate of responding to the treatment at 80.2% compared to genotypes 1 (73.5%) and 6f (65%). Additionally, patients with genotype 6f showed higher rate of relapsing (25%) compared to genotypes 1 and 3 (14.3% and 16.3%, respectively). In conclusion, this study reported multiple HCV genotypes circulated in Thai patients and the response of different HCV genotypes to PEG-IFN/RBV treatment. J. Med. Virol. 86:1360-1365, 2014. © 2014 Wiley Periodicals, Inc.
format Journal
author Kattareeya Kumthip
Pattranuch Chusri
Chansom Pantip
Satawat Thongsawat
Amornrat O'Brien
Kenrad E. Nelson
Niwat Maneekarn
author_facet Kattareeya Kumthip
Pattranuch Chusri
Chansom Pantip
Satawat Thongsawat
Amornrat O'Brien
Kenrad E. Nelson
Niwat Maneekarn
author_sort Kattareeya Kumthip
title Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
title_short Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
title_full Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
title_fullStr Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
title_full_unstemmed Hepatitis C virus genotypes circulating in patients with chronic hepatitis C in Thailand and their responses to combined PEG-IFN and RBV therapy
title_sort hepatitis c virus genotypes circulating in patients with chronic hepatitis c in thailand and their responses to combined peg-ifn and rbv therapy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84901801479&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53618
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