Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin

The final goal of the study was to promote understanding of mechanisms involved in cell attachment on biomedical polymer poly(lactic acid) (PLA). As the cell attachment on the material surface was preceded by blood protein adsorption which would critically affect subsequent cell adhesion, for the cl...

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Main Authors: S. Sarapirom, L. D. Yu, D. Boonyawan, C. Chaiwong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53630
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-536302018-09-04T09:53:32Z Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin S. Sarapirom L. D. Yu D. Boonyawan C. Chaiwong Materials Science The final goal of the study was to promote understanding of mechanisms involved in cell attachment on biomedical polymer poly(lactic acid) (PLA). As the cell attachment on the material surface was preceded by blood protein adsorption which would critically affect subsequent cell adhesion, for the clinic application purpose, human serum albumin (HSA) was used in the investigation on its adsorption on PLA, which was however treated by low-pressure ammonia (NH3) plasma. The NH3-plasma-treated PLA was found to adsorb less HSA than the untreated PLA. The PLA was characterized using various techniques such as atomic force microscopy, contact angle and surface energy analysis and x-ray photoelectron spectroscopy. All of the characterization results indicated that due to NH3-plasma-induced polar groups the PLA enhanced its hydrophilicity which in turn inhibited the HSA adsorption. The decreased HSA adsorption would consequently increase the cell attachment because of the cell adhesion barrier reduced. © 2014 Elsevier B.V. 2018-09-04T09:53:32Z 2018-09-04T09:53:32Z 2014-08-15 Journal 01694332 2-s2.0-84903300385 10.1016/j.apsusc.2014.03.141 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903300385&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53630
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Materials Science
spellingShingle Materials Science
S. Sarapirom
L. D. Yu
D. Boonyawan
C. Chaiwong
Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
description The final goal of the study was to promote understanding of mechanisms involved in cell attachment on biomedical polymer poly(lactic acid) (PLA). As the cell attachment on the material surface was preceded by blood protein adsorption which would critically affect subsequent cell adhesion, for the clinic application purpose, human serum albumin (HSA) was used in the investigation on its adsorption on PLA, which was however treated by low-pressure ammonia (NH3) plasma. The NH3-plasma-treated PLA was found to adsorb less HSA than the untreated PLA. The PLA was characterized using various techniques such as atomic force microscopy, contact angle and surface energy analysis and x-ray photoelectron spectroscopy. All of the characterization results indicated that due to NH3-plasma-induced polar groups the PLA enhanced its hydrophilicity which in turn inhibited the HSA adsorption. The decreased HSA adsorption would consequently increase the cell attachment because of the cell adhesion barrier reduced. © 2014 Elsevier B.V.
format Journal
author S. Sarapirom
L. D. Yu
D. Boonyawan
C. Chaiwong
author_facet S. Sarapirom
L. D. Yu
D. Boonyawan
C. Chaiwong
author_sort S. Sarapirom
title Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
title_short Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
title_full Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
title_fullStr Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
title_full_unstemmed Effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
title_sort effect of surface modification of poly(lactic acid) by low-pressure ammonia plasma on adsorption of human serum albumin
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903300385&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53630
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