Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV

Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age-and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and per...

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Main Authors: Stephen J. Kerr, Thanyawee Puthanakit, Ung Vibol, Linda Aurpibul, Sophan Vonthanak, Pope Kosalaraksa, Suparat Kanjanavanit, Rawiwan Hansudewechakul, Jurai Wongsawat, Wicharn Luesomboon, Kattiya Ratanadilok, Wasana Prasitsuebsai, Kanchana Pruksakaew, Jasper Van Der Lugt, Robert Paul, Jintanat Ananworanich, Victor Valcour
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53710
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-537102018-09-04T10:02:18Z Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV Stephen J. Kerr Thanyawee Puthanakit Ung Vibol Linda Aurpibul Sophan Vonthanak Pope Kosalaraksa Suparat Kanjanavanit Rawiwan Hansudewechakul Jurai Wongsawat Wicharn Luesomboon Kattiya Ratanadilok Wasana Prasitsuebsai Kanchana Pruksakaew Jasper Van Der Lugt Robert Paul Jintanat Ananworanich Victor Valcour Medicine Psychology Social Sciences Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age-and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and perinatally, or differences in the environment in which they grow up. This study assessed neurodevelopmental outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children enrolled as controls in a multicenter ND study from Thailand and Cambodia. One hundred sixty HEU and 167 HUU children completed a neurodevelopmental assessment using the Beery Visual Motor Integration (VMI) test, Color Trails, Perdue Pegboard, and Child Behavior Checklist (CBCL). Thai children (n = 202) also completed the Wechsler Intelligence Scale (IQ) and Stanford-Binet II memory tests. In analyses adjusted for caregiver education, parent as caregiver, household income, age, and ethnicity, statistically significant lower scores were seen on verbal IQ (VIQ), full-scale IQ (FSIQ), and Binet Bead Memory among HEU compared to HUU. The mean (95% CI) differences were-6.13 (-10.3 to-1.96), p = 0.004;-4.57 (-8.80 to-0.35), p = 0.03; and-3.72 (-6.57 to-0.88), p = 0.01 for VIQ, FSIQ, and Binet Bead Memory, respectively. We observed no significant differences in performance IQ, other Binet memory domains, Color Trail, Perdue Pegboard, Beery VMI, or CBCL test scores. We conclude that HEU children evidence reductions in some neurodevelopmental outcomes compared to HUU; however, these differences are small and it remains unclear to what extent they have immediate and long-term clinical significance. © 2014 Taylor and Francis. 2018-09-04T09:56:21Z 2018-09-04T09:56:21Z 2014-11-02 Journal 13600451 09540121 2-s2.0-84905665102 10.1080/09540121.2014.920949 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905665102&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53710
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Psychology
Social Sciences
spellingShingle Medicine
Psychology
Social Sciences
Stephen J. Kerr
Thanyawee Puthanakit
Ung Vibol
Linda Aurpibul
Sophan Vonthanak
Pope Kosalaraksa
Suparat Kanjanavanit
Rawiwan Hansudewechakul
Jurai Wongsawat
Wicharn Luesomboon
Kattiya Ratanadilok
Wasana Prasitsuebsai
Kanchana Pruksakaew
Jasper Van Der Lugt
Robert Paul
Jintanat Ananworanich
Victor Valcour
Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
description Human immunodeficiency virus (HIV)-negative children born to HIV-infected mothers may exhibit differences in neurodevelopment (ND) compared to age-and gender-matched controls whose lives have not been affected by HIV. This could occur due to exposure to HIV and antiretroviral agents in utero and perinatally, or differences in the environment in which they grow up. This study assessed neurodevelopmental outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children enrolled as controls in a multicenter ND study from Thailand and Cambodia. One hundred sixty HEU and 167 HUU children completed a neurodevelopmental assessment using the Beery Visual Motor Integration (VMI) test, Color Trails, Perdue Pegboard, and Child Behavior Checklist (CBCL). Thai children (n = 202) also completed the Wechsler Intelligence Scale (IQ) and Stanford-Binet II memory tests. In analyses adjusted for caregiver education, parent as caregiver, household income, age, and ethnicity, statistically significant lower scores were seen on verbal IQ (VIQ), full-scale IQ (FSIQ), and Binet Bead Memory among HEU compared to HUU. The mean (95% CI) differences were-6.13 (-10.3 to-1.96), p = 0.004;-4.57 (-8.80 to-0.35), p = 0.03; and-3.72 (-6.57 to-0.88), p = 0.01 for VIQ, FSIQ, and Binet Bead Memory, respectively. We observed no significant differences in performance IQ, other Binet memory domains, Color Trail, Perdue Pegboard, Beery VMI, or CBCL test scores. We conclude that HEU children evidence reductions in some neurodevelopmental outcomes compared to HUU; however, these differences are small and it remains unclear to what extent they have immediate and long-term clinical significance. © 2014 Taylor and Francis.
format Journal
author Stephen J. Kerr
Thanyawee Puthanakit
Ung Vibol
Linda Aurpibul
Sophan Vonthanak
Pope Kosalaraksa
Suparat Kanjanavanit
Rawiwan Hansudewechakul
Jurai Wongsawat
Wicharn Luesomboon
Kattiya Ratanadilok
Wasana Prasitsuebsai
Kanchana Pruksakaew
Jasper Van Der Lugt
Robert Paul
Jintanat Ananworanich
Victor Valcour
author_facet Stephen J. Kerr
Thanyawee Puthanakit
Ung Vibol
Linda Aurpibul
Sophan Vonthanak
Pope Kosalaraksa
Suparat Kanjanavanit
Rawiwan Hansudewechakul
Jurai Wongsawat
Wicharn Luesomboon
Kattiya Ratanadilok
Wasana Prasitsuebsai
Kanchana Pruksakaew
Jasper Van Der Lugt
Robert Paul
Jintanat Ananworanich
Victor Valcour
author_sort Stephen J. Kerr
title Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
title_short Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
title_full Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
title_fullStr Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
title_full_unstemmed Neurodevelopmental outcomes in HIV-exposed-uninfected children versus those not exposed to HIV
title_sort neurodevelopmental outcomes in hiv-exposed-uninfected children versus those not exposed to hiv
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905665102&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53710
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