Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy

Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy

A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms' tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examinati...

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Main Authors: Panadeekarn Panjawatanan, Pimlak Charoenkwan, Kamornwan Katanyuwong, Worawut Choeyprasert
Format: Journal
Published: 2018
Subjects:
Medicine
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903643130&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53727
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-537272018-09-04T09:56:40Z Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy Panadeekarn Panjawatanan Pimlak Charoenkwan Kamornwan Katanyuwong Worawut Choeyprasert Medicine A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms' tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examination were normal. A nerve conduction velocity study which was performed on the peripheral nerves revealed predominant motor polyneuropathy compatible with axonal loss involving the upper limbs. The patient had received a cumulative vincristine dose of 17 mg/m2 before developing esotropia. Vincristineinduced abducens nerve mononeuropathy and subclinical motor polyneuropathy was suspected. Unilateral esotropia markedly improved after the discontinuation of vincristine and a short course of oral pyridoxine treatment. Copyright © 2014 BMJ Publishing Group. 2018-09-04T09:56:40Z 2018-09-04T09:56:40Z 2014-06-25 Journal 1757790X 2-s2.0-84903643130 10.1136/bcr-2014-204524 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903643130&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53727
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Panadeekarn Panjawatanan
Pimlak Charoenkwan
Kamornwan Katanyuwong
Worawut Choeyprasert
Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
description A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms' tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examination were normal. A nerve conduction velocity study which was performed on the peripheral nerves revealed predominant motor polyneuropathy compatible with axonal loss involving the upper limbs. The patient had received a cumulative vincristine dose of 17 mg/m2 before developing esotropia. Vincristineinduced abducens nerve mononeuropathy and subclinical motor polyneuropathy was suspected. Unilateral esotropia markedly improved after the discontinuation of vincristine and a short course of oral pyridoxine treatment. Copyright © 2014 BMJ Publishing Group.
format Journal
author Panadeekarn Panjawatanan
Pimlak Charoenkwan
Kamornwan Katanyuwong
Worawut Choeyprasert
author_facet Panadeekarn Panjawatanan
Pimlak Charoenkwan
Kamornwan Katanyuwong
Worawut Choeyprasert
author_sort Panadeekarn Panjawatanan
title Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
title_short Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
title_full Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
title_fullStr Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
title_full_unstemmed Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy
title_sort vincristine-induced polyneuropathy in a child with stage i wilms' tumour presenting with unilateral abducens nerve palsy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903643130&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53727
_version_ 1681424189001564160

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