Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia

• Main Authors: Praphan Phanuphak, Sunee Sirivichayakul, Awachana Jiamsakul, Somnuek Sungkanuparph, Nagalingeswaran Kumarasamy, Man Po Lee, Thira Sirisanthana, Pacharee Kantipong, Christopher Lee, Adeeba Kamarulzaman, Mahiran Mustafa, Rossana Ditangco, Tuti Merati, Winai Ratanasuwan, Thida Singtoroj, Rami Kantor
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898539282&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53737
• Institution: Chiang Mai University

BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs. © 2013 by Lippincott Williams and Wilkins.