Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa

A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis....

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Main Authors:	Chiramet Auranwiwat, Kongkiat Trisuwan, Aroonchai Saiai, Stephen G. Pyne, Thunwadee Ritthiwigrom
Format:	Journal
Published:	2018
Subjects:	Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907346833&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53811
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-53811
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spelling	th-cmuir.6653943832-538112018-09-04T10:00:32Z Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa Chiramet Auranwiwat Kongkiat Trisuwan Aroonchai Saiai Stephen G. Pyne Thunwadee Ritthiwigrom Medicine Pharmacology, Toxicology and Pharmaceutics A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their antibacterial activity against Bacillus cereus TISTR 688, Bacillus subtilis TISTR 008, Micrococcus luteus TISTR 884, Staphylococcus aureus TISTR 1466, Escherichia coli TISTR 780, Pseudomonas aeruginosa TISTR 781, Salmonella typhimurium TISTR 292 and Staphylococcus epidermidis ATCC 12228. α-Mangostin showed potent activity (MIC 0.25-1 μg/mL) against three Gram-positive strains and garcicowanone A and β-mangostin exhibited strong antibacterial activity against B. cereus with the same MIC values of 0.25 μg/mL. © 2014 Elsevier B.V. All rights reserved. 2018-09-04T09:58:34Z 2018-09-04T09:58:34Z 2014-01-01 Journal 18736971 0367326X 2-s2.0-84907346833 10.1016/j.fitote.2014.08.003 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907346833&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53811
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Medicine Pharmacology, Toxicology and Pharmaceutics Chiramet Auranwiwat Kongkiat Trisuwan Aroonchai Saiai Stephen G. Pyne Thunwadee Ritthiwigrom Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
description	A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their antibacterial activity against Bacillus cereus TISTR 688, Bacillus subtilis TISTR 008, Micrococcus luteus TISTR 884, Staphylococcus aureus TISTR 1466, Escherichia coli TISTR 780, Pseudomonas aeruginosa TISTR 781, Salmonella typhimurium TISTR 292 and Staphylococcus epidermidis ATCC 12228. α-Mangostin showed potent activity (MIC 0.25-1 μg/mL) against three Gram-positive strains and garcicowanone A and β-mangostin exhibited strong antibacterial activity against B. cereus with the same MIC values of 0.25 μg/mL. © 2014 Elsevier B.V. All rights reserved.
format	Journal
author	Chiramet Auranwiwat Kongkiat Trisuwan Aroonchai Saiai Stephen G. Pyne Thunwadee Ritthiwigrom
author_facet	Chiramet Auranwiwat Kongkiat Trisuwan Aroonchai Saiai Stephen G. Pyne Thunwadee Ritthiwigrom
author_sort	Chiramet Auranwiwat
title	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
title_short	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
title_full	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
title_fullStr	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
title_full_unstemmed	Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa
title_sort	antibacterial tetraoxygenated xanthones from the immature fruits of garcinia cowa
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907346833&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53811
_version_	1681424204474351616

Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa

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