The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University
Purpose: To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang...
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th-cmuir.6653943832-538262018-09-04T09:58:54Z The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University Ekkasit Tharavichtikul Pooriwat Meungwong Taned Chitapanarux Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Somsak Wanwilairat Patrinee Traisathit Razvan Galalae Imjai Chitapanarux Medicine Purpose: To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Materials and Methods: Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Results: Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale ≥ grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). Conclusion: The cumulative rectal dose in EQD2 >65 Gy have association with ≥ grade 2 LENT-SOMA scale. © 2014. The Korean Society for Radiation Oncology. 2018-09-04T09:58:54Z 2018-09-04T09:58:54Z 2014-01-01 Journal 22343164 22341900 2-s2.0-84904488761 10.3857/roj.2014.32.2.57 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904488761&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53826 |
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Medicine Ekkasit Tharavichtikul Pooriwat Meungwong Taned Chitapanarux Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Somsak Wanwilairat Patrinee Traisathit Razvan Galalae Imjai Chitapanarux The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
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Purpose: To evaluate association between equivalent dose in 2 Gy (EQD2) to rectal point dose and gastrointestinal toxicity from whole pelvic radiotherapy (WPRT) and intracavitary brachytherapy (ICBT) in cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University. Materials and Methods: Retrospective study was designed for the patients with locally advanced cervical cancer, treated by radical radiotherapy from 2004 to 2009 and were evaluated by rectosigmoidoscopy. The cumulative doses of WPRT and ICBT to the maximally rectal point were calculated to the EQD2 and evaluated the association of toxicities. Results: Thirty-nine patients were evaluated for late rectal toxicity. The mean cumulative dose in term of EQD2 to rectum was 64.2 Gy. Grade 1 toxicities were the most common findings. According to endoscopic exam, the most common toxicities were congested mucosa (36 patients) and telangiectasia (32 patients). In evaluation between rectal dose in EQD2 and toxicities, no association of cumulative rectal dose to rectal toxicity, except the association of cumulative rectal dose in EQD2 >65 Gy to late effects of normal tissue (LENT-SOMA) scale ≥ grade 2 (p = 0.022; odds ratio, 5.312; 95% confidence interval, 1.269-22.244). Conclusion: The cumulative rectal dose in EQD2 >65 Gy have association with ≥ grade 2 LENT-SOMA scale. © 2014. The Korean Society for Radiation Oncology. |
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Ekkasit Tharavichtikul Pooriwat Meungwong Taned Chitapanarux Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Somsak Wanwilairat Patrinee Traisathit Razvan Galalae Imjai Chitapanarux |
author_facet |
Ekkasit Tharavichtikul Pooriwat Meungwong Taned Chitapanarux Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Somsak Wanwilairat Patrinee Traisathit Razvan Galalae Imjai Chitapanarux |
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Ekkasit Tharavichtikul |
title |
The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
title_short |
The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
title_full |
The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
title_fullStr |
The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
title_full_unstemmed |
The association of rectal equivalent dose in 2 Gy fractions (EQD2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in Faculty of Medicine, Chiang Mai University |
title_sort |
association of rectal equivalent dose in 2 gy fractions (eqd2) to late rectal toxicity in locally advanced cervical cancer patients who were evaluated by rectosigmoidoscopy in faculty of medicine, chiang mai university |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904488761&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53826 |
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