Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: Results from the phase 3 HPTN 052 randomised controlled trial

• Main Authors: Beatriz Grinsztejn, Mina C. Hosseinipour, Heather J. Ribaudo, Susan Swindells, Joseph Eron, Ying Q. Chen, Lei Wang, San San Ou, Maija Anderson, Marybeth McCauley, Theresa Gamble, Nagalingeshwaran Kumarasamy, James G. Hakim, Johnstone Kumwenda, Jose H.S. Pilotto, Sheela V. Godbole, Suwat Chariyalertsak, Marineide Gonçalves De Melo, Kenneth H. Mayer, Susan H. Eshleman, Estelle Piwowar-Manning, Joseph Makhema, Lisa A. Mills, Ravindre Panchia, Ian Sanne, Joel Gallant, Irving Hoffman, Taha E. Taha, Karin Nielsen-Saines, David Celentano, Max Essex, Diane Havlir, Myron S. Cohen
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896493594&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53870
• Institution: Chiang Mai University

Background: Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to initiate antiretroviral treatment to reduce progression of HIV-1 infection or non-AIDS clinical events is unknown. W...