Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical

Objective: Aging process causes the skin problems that can be prevented by using effective cosmeceuticals with antioxidant activity. Our previous study demonstrated that ethyl acetate marigold flower extract (EA) consisting the flavonoids that exhibited potent antioxidant activity with safe. Therefo...

Full description

Saved in:
Bibliographic Details
Main Authors: Pimporn Leelapornpisid, Kanokwan Kiattisin, Pensak Jantrawut, Ampai Phrutivorapongkul
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897145422&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53890
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-53890
record_format dspace
spelling th-cmuir.6653943832-538902018-09-04T10:00:26Z Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical Pimporn Leelapornpisid Kanokwan Kiattisin Pensak Jantrawut Ampai Phrutivorapongkul Pharmacology, Toxicology and Pharmaceutics Objective: Aging process causes the skin problems that can be prevented by using effective cosmeceuticals with antioxidant activity. Our previous study demonstrated that ethyl acetate marigold flower extract (EA) consisting the flavonoids that exhibited potent antioxidant activity with safe. Therefore, the EA loaded nanoemulsion was prepared and incorporated into a gel base for anti-wrinkles purpose. Methods: The gel containing nanoemulsion loaded with EA (EANG) was investigated physical properties and antioxidant activity (DPPH assay) at before and after various storage conditions for 3 months. The in vitro skin permeation study was also carried out. Skin irritation test, clinical evaluation for skin moisturizing effect and skin wrinkles-reducing capability were finally performed in thirty healthy human volunteers for 8 weeks. Results: The results showed that the EANG was physically stable and exhibited good stability in antioxidant activity after various storage conditions. From the in vitro permeation test, a major compound: quercetagetin in the EANG was mostly remained in stratum corneum, viable epidermis and dermis rather than in blood circulation which was related to cosmetic purpose. The results from clinical evaluation revealed that the skin hydration was significantly increased after using the EANG. In addition, it showed significant reduction in all wrinkle parameters (surface, volume, Ra and Rz). The percentages of efficiency between EANG area and placebo area were also significantly different in terms of volume, Ra and Rz. Conclusion: Our results strongly indicated that the gel containing nanoemulsion loaded with marigold flower extract was a promising anti-wrinkles cosmeceutical. 2018-09-04T10:00:26Z 2018-09-04T10:00:26Z 2014-01-01 Journal 09751491 2-s2.0-84897145422 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897145422&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53890
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Pimporn Leelapornpisid
Kanokwan Kiattisin
Pensak Jantrawut
Ampai Phrutivorapongkul
Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
description Objective: Aging process causes the skin problems that can be prevented by using effective cosmeceuticals with antioxidant activity. Our previous study demonstrated that ethyl acetate marigold flower extract (EA) consisting the flavonoids that exhibited potent antioxidant activity with safe. Therefore, the EA loaded nanoemulsion was prepared and incorporated into a gel base for anti-wrinkles purpose. Methods: The gel containing nanoemulsion loaded with EA (EANG) was investigated physical properties and antioxidant activity (DPPH assay) at before and after various storage conditions for 3 months. The in vitro skin permeation study was also carried out. Skin irritation test, clinical evaluation for skin moisturizing effect and skin wrinkles-reducing capability were finally performed in thirty healthy human volunteers for 8 weeks. Results: The results showed that the EANG was physically stable and exhibited good stability in antioxidant activity after various storage conditions. From the in vitro permeation test, a major compound: quercetagetin in the EANG was mostly remained in stratum corneum, viable epidermis and dermis rather than in blood circulation which was related to cosmetic purpose. The results from clinical evaluation revealed that the skin hydration was significantly increased after using the EANG. In addition, it showed significant reduction in all wrinkle parameters (surface, volume, Ra and Rz). The percentages of efficiency between EANG area and placebo area were also significantly different in terms of volume, Ra and Rz. Conclusion: Our results strongly indicated that the gel containing nanoemulsion loaded with marigold flower extract was a promising anti-wrinkles cosmeceutical.
format Journal
author Pimporn Leelapornpisid
Kanokwan Kiattisin
Pensak Jantrawut
Ampai Phrutivorapongkul
author_facet Pimporn Leelapornpisid
Kanokwan Kiattisin
Pensak Jantrawut
Ampai Phrutivorapongkul
author_sort Pimporn Leelapornpisid
title Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
title_short Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
title_full Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
title_fullStr Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
title_full_unstemmed Nanoemulsion loaded with marigold flower extract (Tagetes Erecta linn) in gel preparation as anti-wrinkles cosmeceutical
title_sort nanoemulsion loaded with marigold flower extract (tagetes erecta linn) in gel preparation as anti-wrinkles cosmeceutical
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897145422&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53890
_version_ 1681424219191115776