Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated comp...

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Main Authors:	Atchara Jaidee, Thanika Promchai, Kongkiat Trisuwan, Surat Laphookhieo, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Stephen G. Pyne, Thunwadee Ritthiwigrom
Format:	Journal
Published:	2018
Subjects:	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54079
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-540792018-09-04T10:25:20Z Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum Atchara Jaidee Thanika Promchai Kongkiat Trisuwan Surat Laphookhieo Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Ritthiwigrom Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity. 2018-09-04T10:07:27Z 2018-09-04T10:07:27Z 2015-01-01 Journal 15559475 1934578X 2-s2.0-84946913030 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54079
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics Atchara Jaidee Thanika Promchai Kongkiat Trisuwan Surat Laphookhieo Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Ritthiwigrom Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
description	One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.
format	Journal
author	Atchara Jaidee Thanika Promchai Kongkiat Trisuwan Surat Laphookhieo Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Ritthiwigrom
author_facet	Atchara Jaidee Thanika Promchai Kongkiat Trisuwan Surat Laphookhieo Roonglawan Rattanajak Sumalee Kamchonwongpaisan Stephen G. Pyne Thunwadee Ritthiwigrom
author_sort	Atchara Jaidee
title	Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_short	Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_full	Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_fullStr	Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_full_unstemmed	Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
title_sort	cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946913030&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54079
_version_	1681424254262837248

Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum

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