A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media

© 2015 Elsevier Ltd. All rights reserved. A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N-acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammoni...

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Main Authors:	Sirawit Wet-Osot, Mookda Pattarawarapan, Wong Phakhodee
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84949106013&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54095
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-54095
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spelling	th-cmuir.6653943832-540952018-09-04T10:24:45Z A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media Sirawit Wet-Osot Mookda Pattarawarapan Wong Phakhodee Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics © 2015 Elsevier Ltd. All rights reserved. A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N-acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammonium bromide, the reaction of ketones with potassium cyanide and N-acylbenzotriazoles proceeded readily at room temperature to provide the corresponding O-acyl cyanohydrin derivatives in good to excellent yields. 2018-09-04T10:07:41Z 2018-09-04T10:07:41Z 2015-12-30 Journal 18733581 00404039 2-s2.0-84949106013 10.1016/j.tetlet.2015.11.038 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84949106013&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54095
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Sirawit Wet-Osot Mookda Pattarawarapan Wong Phakhodee A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
description	© 2015 Elsevier Ltd. All rights reserved. A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N-acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammonium bromide, the reaction of ketones with potassium cyanide and N-acylbenzotriazoles proceeded readily at room temperature to provide the corresponding O-acyl cyanohydrin derivatives in good to excellent yields.
format	Journal
author	Sirawit Wet-Osot Mookda Pattarawarapan Wong Phakhodee
author_facet	Sirawit Wet-Osot Mookda Pattarawarapan Wong Phakhodee
author_sort	Sirawit Wet-Osot
title	A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
title_short	A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
title_full	A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
title_fullStr	A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
title_full_unstemmed	A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
title_sort	convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84949106013&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54095
_version_	1681424257217724416

A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media

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