Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

• Main Authors: Wasana Pratchayasakul, Piangkwan Sa-nguanmoo, Sivaporn Sivasinprasasn, Hiranya Pintana, Rungroj Tawinvisan, Jirapas Sripetchwandee, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930675858&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/54138
• Institution: Chiang Mai University

© 2015 Elsevier Inc. Chronic consumption of a high-fat diet (HF) causes peripheral insulin resistance, brain insulin resistance, brain mitochondrial dysfunction and cognitive impairment. Estrogen deprivation has also been found to impair cognition. However, the combined effect of both conditions on...