Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities

© 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic...

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Main Author:	Suree Lekawanvijit
Format:	Journal
Published:	2018
Subjects:	Medicine
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54746
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-54746
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spelling	th-cmuir.6653943832-547462018-09-04T10:22:24Z Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities Suree Lekawanvijit Medicine © 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic toxins (PBUTs) by current conventional dialysis remains problematic because of their proteinbinding capacity. Most PBUTs that have been implicated in cardiorenal toxicity have been demonstrated to be derived from a colonic microbiota metabolism pathway using dietary amino acids as a substrate. Currently, indoxyl sulfate and p-cresyl sulfate are the most extensively investigated gut-derived PBUTs. Strong evidence of adverse clinical outcomes, as well as biological toxicity on the kidney and cardiovascular system attributable to these toxins, has been increasingly reported. Regarding their site of origin, the colon has become a potential target for treatment of cardiorenal syndrome induced by gut-derived PBUTs. 2018-09-04T10:22:24Z 2018-09-04T10:22:24Z 2015-01-01 Journal 13474820 13469843 2-s2.0-84942540625 10.1253/circj.CJ-15-0749 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54746
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Medicine
spellingShingle	Medicine Suree Lekawanvijit Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
description	© 2015, Japanese Circulation Society. All rights reserved. Uremic toxins have been increasingly recognized as a crucial missing link in the cardiorenal syndrome. Advances in dialysis technologies have contributed to an enormous improvement in uremic toxin removal, but removal of protein-bound uremic toxins (PBUTs) by current conventional dialysis remains problematic because of their proteinbinding capacity. Most PBUTs that have been implicated in cardiorenal toxicity have been demonstrated to be derived from a colonic microbiota metabolism pathway using dietary amino acids as a substrate. Currently, indoxyl sulfate and p-cresyl sulfate are the most extensively investigated gut-derived PBUTs. Strong evidence of adverse clinical outcomes, as well as biological toxicity on the kidney and cardiovascular system attributable to these toxins, has been increasingly reported. Regarding their site of origin, the colon has become a potential target for treatment of cardiorenal syndrome induced by gut-derived PBUTs.
format	Journal
author	Suree Lekawanvijit
author_facet	Suree Lekawanvijit
author_sort	Suree Lekawanvijit
title	Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_short	Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_full	Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_fullStr	Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_full_unstemmed	Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
title_sort	role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942540625&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54746
_version_	1681424377512460288

Role of gut-derived protein-bound uremic toxins in cardiorenal syndrome and potential treatment modalities

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