Functional importance of the Gly cluster in transmembrane helix 2 of the Bordetella pertussis CyaA-hemolysin: Implications for toxin oligomerization and pore formation

• Main Authors: Sirikran Juntapremjit, Niramon Thamwiriyasati, Chattip Kurehong, Panchika Prangkio, Lalida Shank, Busaba Powthongchin, Chanan Angsuthanasombat
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84941985118&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/54835
• Institution: Chiang Mai University

© 2015 Published by Elsevier Ltd. Adenylate cyclase-hemolysin (CyaA) is a major virulence factor of Bordetella pertussis causing whooping cough in humans. We previously showed that two transmembrane helices (α2 and α3) in the hemolysin domain (CyaA-Hly) are crucially involved in hemolytic activity....