The stability of generic meropenem in tropical countries
© 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved. Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution. Methods: Generic meropenem brand A and brand B vials were used to p...
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th-cmuir.6653943832-548462018-09-04T10:25:10Z The stability of generic meropenem in tropical countries Wasan Katip Purida Wientong Chuleegone Sornsuvit Pharmacology, Toxicology and Pharmaceutics © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved. Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution. Methods: Generic meropenem brand A and brand B vials were used to prepare 10 mg/mL and 20 mg/mL solutions in PVC bags. The prepared solutions were incubated at 25, 30 and 35 °C. Three mL of each solution were with drawn at 0, 4, 8 and 12 hours and subjected to HPLC analysis. Results: Generic meropenem (Brand A) as a 10 mg/mL solution was stable for up to 10 hours at 25°C, 5 hours at 30°C and 4.5 hours at 35°C. A. 20 mg/mL solution was stable for 6 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. Generic meropenem (Brand B) as a 10 mg/mL solution was stable for up to 9 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. A. 20 mg/mL solution was stable for 5 hours at 25°C,10 hours at 30°C and 5 hours at 35°C. Conclusion: The stability of the generic meropenem solutions was affected by temperature and concentration. Higher the temperatures and higher the drug concentrations, show lower the stability of generic meropenem. 2018-09-04T10:25:10Z 2018-09-04T10:25:10Z 2015-01-01 Journal 09751491 2-s2.0-84937541630 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937541630&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54846 |
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Pharmacology, Toxicology and Pharmaceutics Wasan Katip Purida Wientong Chuleegone Sornsuvit The stability of generic meropenem in tropical countries |
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© 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved. Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution. Methods: Generic meropenem brand A and brand B vials were used to prepare 10 mg/mL and 20 mg/mL solutions in PVC bags. The prepared solutions were incubated at 25, 30 and 35 °C. Three mL of each solution were with drawn at 0, 4, 8 and 12 hours and subjected to HPLC analysis. Results: Generic meropenem (Brand A) as a 10 mg/mL solution was stable for up to 10 hours at 25°C, 5 hours at 30°C and 4.5 hours at 35°C. A. 20 mg/mL solution was stable for 6 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. Generic meropenem (Brand B) as a 10 mg/mL solution was stable for up to 9 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. A. 20 mg/mL solution was stable for 5 hours at 25°C,10 hours at 30°C and 5 hours at 35°C. Conclusion: The stability of the generic meropenem solutions was affected by temperature and concentration. Higher the temperatures and higher the drug concentrations, show lower the stability of generic meropenem. |
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Journal |
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Wasan Katip Purida Wientong Chuleegone Sornsuvit |
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Wasan Katip Purida Wientong Chuleegone Sornsuvit |
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Wasan Katip |
title |
The stability of generic meropenem in tropical countries |
title_short |
The stability of generic meropenem in tropical countries |
title_full |
The stability of generic meropenem in tropical countries |
title_fullStr |
The stability of generic meropenem in tropical countries |
title_full_unstemmed |
The stability of generic meropenem in tropical countries |
title_sort |
stability of generic meropenem in tropical countries |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937541630&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54846 |
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