Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata

© 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spe...

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Main Authors:	Thanika Promchai, Atchara Jaidee, Sarot Cheenpracha, Kongkiat Trisuwan, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Surat Laphookhieo, Stephen G. Pyne, Thunwadee Ritthiwigrom
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55216
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-55216
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spelling	th-cmuir.6653943832-552162018-09-05T03:12:18Z Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata Thanika Promchai Atchara Jaidee Sarot Cheenpracha Kongkiat Trisuwan Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Ritthiwigrom Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics © 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC50value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC50value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated. 2018-09-05T02:53:13Z 2018-09-05T02:53:13Z 2016-04-22 Journal 15206025 01633864 2-s2.0-84969695160 10.1021/acs.jnatprod.5b01054 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55216
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Thanika Promchai Atchara Jaidee Sarot Cheenpracha Kongkiat Trisuwan Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Ritthiwigrom Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
description	© 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC50value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC50value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated.
format	Journal
author	Thanika Promchai Atchara Jaidee Sarot Cheenpracha Kongkiat Trisuwan Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Ritthiwigrom
author_facet	Thanika Promchai Atchara Jaidee Sarot Cheenpracha Kongkiat Trisuwan Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Ritthiwigrom
author_sort	Thanika Promchai
title	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_short	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_full	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_fullStr	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_full_unstemmed	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_sort	antimalarial oxoprotoberberine alkaloids from the leaves of miliusa cuneata
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55216
_version_	1681424464591454208

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata

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