Acetylcholinesterase inhibitory activity and molecular docking study of steroidal alkaloids from Holarrhena pubescens barks

• Main Authors: Sarot Cheenpracha, Jitrayut Jitonnom, Manutchaya Komek, Thunwadee Ritthiwigrom, Surat Laphookhieo
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84960805085&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55228
• Institution: Chiang Mai University

© 2016 Elsevier Inc. All rights reserved. An alkaloidal extract of the bark of Holarrhena pubescens showed several inhibition zones of acetylcholinesterase (AChE) inhibitor, using a bioautographic assay. Activity-guided fractionation afforded three new steroidal alkaloids, mokluangins A-C (1-3), tog...