Ultrasound-assisted synthesis of substituted guanidines from thioureas

© 2016 Elsevier Ltd. Ultrasound-assisted synthesis of guanidine derivatives was developed using 2,4,6-trichloro-1,3,5-triazine as an inexpensive dehydrosulfurization reagent. Both 1,3-alkylaryl- and 1,3-diaryl-thioureas were rapidly converted into carbodiimides before subsequent reaction with aromat...

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Main Authors:	Mookda Pattarawarapan, Subin Jaita, Sirilak Wangngae, Wong Phakhodee
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958580862&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55247
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Institution:	Chiang Mai University

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spelling	th-cmuir.6653943832-552472018-09-05T03:12:29Z Ultrasound-assisted synthesis of substituted guanidines from thioureas Mookda Pattarawarapan Subin Jaita Sirilak Wangngae Wong Phakhodee Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics © 2016 Elsevier Ltd. Ultrasound-assisted synthesis of guanidine derivatives was developed using 2,4,6-trichloro-1,3,5-triazine as an inexpensive dehydrosulfurization reagent. Both 1,3-alkylaryl- and 1,3-diaryl-thioureas were rapidly converted into carbodiimides before subsequent reaction with aromatic or aliphatic amines. The method allows rapid access to highly substituted guanidines in good to excellent yields under mild conditions and with minimal use of solvent. 2018-09-05T02:53:35Z 2018-09-05T02:53:35Z 2016-01-15 Journal 18733581 00404039 2-s2.0-84958580862 10.1016/j.tetlet.2016.02.050 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958580862&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55247
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Mookda Pattarawarapan Subin Jaita Sirilak Wangngae Wong Phakhodee Ultrasound-assisted synthesis of substituted guanidines from thioureas
description	© 2016 Elsevier Ltd. Ultrasound-assisted synthesis of guanidine derivatives was developed using 2,4,6-trichloro-1,3,5-triazine as an inexpensive dehydrosulfurization reagent. Both 1,3-alkylaryl- and 1,3-diaryl-thioureas were rapidly converted into carbodiimides before subsequent reaction with aromatic or aliphatic amines. The method allows rapid access to highly substituted guanidines in good to excellent yields under mild conditions and with minimal use of solvent.
format	Journal
author	Mookda Pattarawarapan Subin Jaita Sirilak Wangngae Wong Phakhodee
author_facet	Mookda Pattarawarapan Subin Jaita Sirilak Wangngae Wong Phakhodee
author_sort	Mookda Pattarawarapan
title	Ultrasound-assisted synthesis of substituted guanidines from thioureas
title_short	Ultrasound-assisted synthesis of substituted guanidines from thioureas
title_full	Ultrasound-assisted synthesis of substituted guanidines from thioureas
title_fullStr	Ultrasound-assisted synthesis of substituted guanidines from thioureas
title_full_unstemmed	Ultrasound-assisted synthesis of substituted guanidines from thioureas
title_sort	ultrasound-assisted synthesis of substituted guanidines from thioureas
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958580862&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55247
_version_	1681424470411051008

Ultrasound-assisted synthesis of substituted guanidines from thioureas

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