Testosterone deprivation accelerates cardiac dysfunction in obese male rats

© 2016 Society for Endocrinology. Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggrav...

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Main Authors: Wanpitak Pongkan, Hiranya Pintana, Sivaporn Sivasinprasasn, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/55254
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spelling th-cmuir.6653943832-552542018-09-05T03:10:47Z Testosterone deprivation accelerates cardiac dysfunction in obese male rats Wanpitak Pongkan Hiranya Pintana Sivaporn Sivasinprasasn Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn Biochemistry, Genetics and Molecular Biology Medicine © 2016 Society for Endocrinology. Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggravate the cardiac dysfunction in obese-insulin-resistant subjects. However, the mechanism underlying this adverse effect is unclear. This study investigated the effects of obesity on metabolic parameters, heart rate variability (HRV), left ventricular (LV) function, and cardiac mitochondrial function in testosterone-deprived rats. Orchiectomized or shamoperated male Wistar rats (n = 36 per group) were randomly divided into groups and were given either a normal diet (ND, 19.77% of energy fat) or a high-fat diet (HFD, 57.60% of energy fat) for 12 weeks. Metabolic parameters, HRV, LV function, and cardiac mitochondrial function were determined at 4, 8, and 12 weeks after starting each feeding program. We found that insulin resistance was observed after 8 weeks of the consumption of a HFD in both sham (HFS) and orchiectomized (HFO) rats. Neither the ND sham (NDS) group nor ND orchiectomized (NDO) rats developed insulin resistance. The development of depressed HRV, LV contractile dysfunction, and increased cardiac mitochondrial reactive oxygen species production was observed earlier in orchiectomized (NDO and HFO) rats at week 4, whereas HFS rats exhibited these impairments later at week 8. These findings suggest that testosterone deprivation accelerates the impairment of cardiac autonomic regulation and LV function via increased oxidative stress and impaired cardiac mitochondrial function in obese-orchiectomized male rats. 2018-09-05T02:53:40Z 2018-09-05T02:53:40Z 2016-01-01 Journal 14796805 00220795 2-s2.0-84977623217 10.1530/JOE-16-0002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84977623217&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55254
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Wanpitak Pongkan
Hiranya Pintana
Sivaporn Sivasinprasasn
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
Testosterone deprivation accelerates cardiac dysfunction in obese male rats
description © 2016 Society for Endocrinology. Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggravate the cardiac dysfunction in obese-insulin-resistant subjects. However, the mechanism underlying this adverse effect is unclear. This study investigated the effects of obesity on metabolic parameters, heart rate variability (HRV), left ventricular (LV) function, and cardiac mitochondrial function in testosterone-deprived rats. Orchiectomized or shamoperated male Wistar rats (n = 36 per group) were randomly divided into groups and were given either a normal diet (ND, 19.77% of energy fat) or a high-fat diet (HFD, 57.60% of energy fat) for 12 weeks. Metabolic parameters, HRV, LV function, and cardiac mitochondrial function were determined at 4, 8, and 12 weeks after starting each feeding program. We found that insulin resistance was observed after 8 weeks of the consumption of a HFD in both sham (HFS) and orchiectomized (HFO) rats. Neither the ND sham (NDS) group nor ND orchiectomized (NDO) rats developed insulin resistance. The development of depressed HRV, LV contractile dysfunction, and increased cardiac mitochondrial reactive oxygen species production was observed earlier in orchiectomized (NDO and HFO) rats at week 4, whereas HFS rats exhibited these impairments later at week 8. These findings suggest that testosterone deprivation accelerates the impairment of cardiac autonomic regulation and LV function via increased oxidative stress and impaired cardiac mitochondrial function in obese-orchiectomized male rats.
format Journal
author Wanpitak Pongkan
Hiranya Pintana
Sivaporn Sivasinprasasn
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_facet Wanpitak Pongkan
Hiranya Pintana
Sivaporn Sivasinprasasn
Thidarat Jaiwongkam
Siriporn C. Chattipakorn
Nipon Chattipakorn
author_sort Wanpitak Pongkan
title Testosterone deprivation accelerates cardiac dysfunction in obese male rats
title_short Testosterone deprivation accelerates cardiac dysfunction in obese male rats
title_full Testosterone deprivation accelerates cardiac dysfunction in obese male rats
title_fullStr Testosterone deprivation accelerates cardiac dysfunction in obese male rats
title_full_unstemmed Testosterone deprivation accelerates cardiac dysfunction in obese male rats
title_sort testosterone deprivation accelerates cardiac dysfunction in obese male rats
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84977623217&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/55254
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