Antimicrobial activities of fungi derived from the gorgonian sea fan Annella sp. & their metabolites
© 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved. One hundred and sixty-three fungi isolated from gorgonian sea fan Annella sp. were screened for antimicrobial activity against human pathogens. Forty-seven percents of the isolates produced...
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| Main Authors: | , , , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006868239&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55636 |
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| Institution: | Chiang Mai University |
| Summary: | © 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved. One hundred and sixty-three fungi isolated from gorgonian sea fan Annella sp. were screened for antimicrobial activity against human pathogens. Forty-seven percents of the isolates produced antimicrobial metabolites against at least one pathogen with minimum inhibitory concentrations (MIC) ranged from 1 to 1,280 µg mL-1. Crude extracts from 16%, 21%, 18% and 23% of the isolates inhibited standard strain of Staphylococcus aureus, methicillin-resistant S. aureus, Escherichia coli and Pseudomonas aeruginosa, respectively. Eighteen percents of the isolates displayed antifungal activity against Microsporum gypseum while only 3% inhibited Cryptoccocus neoformans and Candida albicans. Potential isolates were identified by morphological and molecular characteristics. Twenty-nine pure compounds isolated from ten isolates were evaluated for antimicrobial activity. Griseofulvin from Nigrospora sp. PSU-F13 exhibited the best activity against M. gypseum (MIC 2 µg mL-1). The result indicates that sea fan-derived fungi are a potential source of antimicrobial agents. |
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