Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application

© 2016 Trans Tech Publications, Switzerland. This study reports the effects of the mixing ratio of hydroxyapatite (HA), silk fibroin (SF) and chitosan (CS) on the physical properties of the scaffold used in tissue engineering. Experimental design based on mixture design was implemented to investigat...

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Main Authors: Wassanai Wattanutchariya, Atitaya Oonjai, Kittiya Thunsiri
Format: Book Series
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988664231&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/55795
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-557952018-09-05T03:14:04Z Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application Wassanai Wattanutchariya Atitaya Oonjai Kittiya Thunsiri Engineering Materials Science Physics and Astronomy © 2016 Trans Tech Publications, Switzerland. This study reports the effects of the mixing ratio of hydroxyapatite (HA), silk fibroin (SF) and chitosan (CS) on the physical properties of the scaffold used in tissue engineering. Experimental design based on mixture design was implemented to investigate the degradation rate of the scaffolds fabricated from various ratios of those biomaterials. Furthermore, pore morphology and pore size were evaluated to confirm the compatibility of the scaffold topography for cell growth and adhesion. The results from the study showed that all ratios, except pure HA solution, can be fabricated into porous scaffolds with an interconnected pore structure and appropriate pore sizes to allow all types of human cells to pass through. Furthermore, the scaffold solutions with high CS ratio resulted in a uniform pore structure and lower rates of biodegradation. Therefore, CS is recommended as the main structure because it provides the highest resistance to biodegradation. The scaffolds from various ratios may be applied for different tissue replacements in the near future. 2018-09-05T03:01:31Z 2018-09-05T03:01:31Z 2016-01-01 Book Series 02555476 2-s2.0-84988664231 10.4028/www.scientific.net/MSF.872.261 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988664231&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55795
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Engineering
Materials Science
Physics and Astronomy
spellingShingle Engineering
Materials Science
Physics and Astronomy
Wassanai Wattanutchariya
Atitaya Oonjai
Kittiya Thunsiri
Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
description © 2016 Trans Tech Publications, Switzerland. This study reports the effects of the mixing ratio of hydroxyapatite (HA), silk fibroin (SF) and chitosan (CS) on the physical properties of the scaffold used in tissue engineering. Experimental design based on mixture design was implemented to investigate the degradation rate of the scaffolds fabricated from various ratios of those biomaterials. Furthermore, pore morphology and pore size were evaluated to confirm the compatibility of the scaffold topography for cell growth and adhesion. The results from the study showed that all ratios, except pure HA solution, can be fabricated into porous scaffolds with an interconnected pore structure and appropriate pore sizes to allow all types of human cells to pass through. Furthermore, the scaffold solutions with high CS ratio resulted in a uniform pore structure and lower rates of biodegradation. Therefore, CS is recommended as the main structure because it provides the highest resistance to biodegradation. The scaffolds from various ratios may be applied for different tissue replacements in the near future.
format Book Series
author Wassanai Wattanutchariya
Atitaya Oonjai
Kittiya Thunsiri
author_facet Wassanai Wattanutchariya
Atitaya Oonjai
Kittiya Thunsiri
author_sort Wassanai Wattanutchariya
title Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
title_short Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
title_full Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
title_fullStr Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
title_full_unstemmed Effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
title_sort effects of hydroxyapatite/silk fibroin/chitosan ratio on physical properties of scaffold for tissue engineering application
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988664231&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/55795
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