Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women

© 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht. In Cadmium (Cd)-exposed populations there is urinary calcium (Ca) loss which reflects Ca loss from the bone, decreased bone mass, and osteoporosis later in life, to which women a...

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Main Authors: Kowit Nambunmee, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/55853
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-558532018-09-05T03:12:02Z Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women Kowit Nambunmee Witaya Swaddiwudhipong Werawan Ruangyuttikarn Environmental Science Pharmacology, Toxicology and Pharmaceutics © 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht. In Cadmium (Cd)-exposed populations there is urinary calcium (Ca) loss which reflects Ca loss from the bone, decreased bone mass, and osteoporosis later in life, to which women are particularly vulnerable. A sensitive screening method to detect critical Ca wasting is required to provide warning of an increased osteoporosis risk. We used Fractional Excretion of Calcium (FECa) to study Ca wasting in Cd-exposed population. FECa sensitivity to Ca loss was compared to that of serum Ca, urinary Ca and intact parathyroid hormone. Mean FECa in the exposed group was 1.5 times higher than in the control group, and a dose-effect relationship to Cd exposure level was observed. FECa showed a relationship to Cd exposure level even following adjustment for a renal dysfunction marker. We conclude that FECa has a better sensitivity than urinary Ca and serum Ca. The use of FECa as an indicator of Ca wasting in Cd exposed women is recommended. 2018-09-05T03:02:22Z 2018-09-05T03:02:22Z 2016-12-01 Journal 22337784 20059752 2-s2.0-85008193701 10.1007/s13530-016-0290-0 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008193701&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55853
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Environmental Science
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Environmental Science
Pharmacology, Toxicology and Pharmaceutics
Kowit Nambunmee
Witaya Swaddiwudhipong
Werawan Ruangyuttikarn
Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
description © 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht. In Cadmium (Cd)-exposed populations there is urinary calcium (Ca) loss which reflects Ca loss from the bone, decreased bone mass, and osteoporosis later in life, to which women are particularly vulnerable. A sensitive screening method to detect critical Ca wasting is required to provide warning of an increased osteoporosis risk. We used Fractional Excretion of Calcium (FECa) to study Ca wasting in Cd-exposed population. FECa sensitivity to Ca loss was compared to that of serum Ca, urinary Ca and intact parathyroid hormone. Mean FECa in the exposed group was 1.5 times higher than in the control group, and a dose-effect relationship to Cd exposure level was observed. FECa showed a relationship to Cd exposure level even following adjustment for a renal dysfunction marker. We conclude that FECa has a better sensitivity than urinary Ca and serum Ca. The use of FECa as an indicator of Ca wasting in Cd exposed women is recommended.
format Journal
author Kowit Nambunmee
Witaya Swaddiwudhipong
Werawan Ruangyuttikarn
author_facet Kowit Nambunmee
Witaya Swaddiwudhipong
Werawan Ruangyuttikarn
author_sort Kowit Nambunmee
title Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
title_short Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
title_full Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
title_fullStr Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
title_full_unstemmed Fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
title_sort fractional excretion of calcium, a sensitive marker for calcium wasting in cadmium-exposed women
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008193701&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/55853
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