Fibroin membrane preparation and stabilization by polyethylene glycol diglycidyl ether

Membranes prepared by drying aqueous Bombyx mori silk fibroin (SF) solution and modified silk fibroin (MSF) solutions, prepared by adding the low molecular weight crosslinking agent, polyethylene glycol diglycidyl ether (PEGDE) MW 526, 0-10% w/w, were investigated by Scanning Electron Microscopy (SE...

Full description

Saved in:
Bibliographic Details
Main Authors: Moonsri P., Watanesk R., Watanesk S., Niamsup H., Deming R.L.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-42049086954&partnerID=40&md5=da8a1c484b16dab7a76b5be912dff399
http://cmuir.cmu.ac.th/handle/6653943832/5599
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
Description
Summary:Membranes prepared by drying aqueous Bombyx mori silk fibroin (SF) solution and modified silk fibroin (MSF) solutions, prepared by adding the low molecular weight crosslinking agent, polyethylene glycol diglycidyl ether (PEGDE) MW 526, 0-10% w/w, were investigated by Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and UV-vis spectroscopy. Weight gain in aqueous solutions and their mechanical properties (tensile strength, elongation, and Young's modulus) were then characterized. SEM measurements revealed greater porosity in MSF membranes. IR spectra showed transformation from the largely α-helical/random coil structures in SF membranes to predominantly β-sheet in MSF membranes. Results from UV-vis spectroscopy showed that the MSF membranes were largely insoluble within the pH range of 4-10. Water absorbability of the MSF membranes improved with increasing the amounts of cross-linker, up to 4%. The MSF membranes showed greater pliability and tenacity, but lower tensile strength, with increasing PEGDE concentrations. In the wet condition, PEGDE levels up to 4% can improve both tensile strength and tenacity of the MSF membrane, but higher levels (up to 10%) did not significantly change these properties. © 2008 Wiley Periodicals, Inc.