Depression and pain: Testing of serial multiple mediators

© 2016 Wongpakaran et al. Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersona...

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Main Authors: Tinakon Wongpakaran, Nahathai Wongpakaran, Sitthinant Tanchakvaranont, Putipong Bookkamana, Manee Pinyopornpanish, Kamonporn Wannarit, Sirina Satthapisit, Daochompu Nakawiro, Thanita Hiranyatheb, Kulvadee Thongpibul
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/56094
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spelling th-cmuir.6653943832-560942018-09-05T03:11:38Z Depression and pain: Testing of serial multiple mediators Tinakon Wongpakaran Nahathai Wongpakaran Sitthinant Tanchakvaranont Putipong Bookkamana Manee Pinyopornpanish Kamonporn Wannarit Sirina Satthapisit Daochompu Nakawiro Thanita Hiranyatheb Kulvadee Thongpibul Medicine Neuroscience © 2016 Wongpakaran et al. Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Results: Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application. 2018-09-05T03:08:51Z 2018-09-05T03:08:51Z 2016-08-16 Journal 11782021 11766328 2-s2.0-84983537488 10.2147/NDT.S110383 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983537488&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56094
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Tinakon Wongpakaran
Nahathai Wongpakaran
Sitthinant Tanchakvaranont
Putipong Bookkamana
Manee Pinyopornpanish
Kamonporn Wannarit
Sirina Satthapisit
Daochompu Nakawiro
Thanita Hiranyatheb
Kulvadee Thongpibul
Depression and pain: Testing of serial multiple mediators
description © 2016 Wongpakaran et al. Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Results: Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application.
format Journal
author Tinakon Wongpakaran
Nahathai Wongpakaran
Sitthinant Tanchakvaranont
Putipong Bookkamana
Manee Pinyopornpanish
Kamonporn Wannarit
Sirina Satthapisit
Daochompu Nakawiro
Thanita Hiranyatheb
Kulvadee Thongpibul
author_facet Tinakon Wongpakaran
Nahathai Wongpakaran
Sitthinant Tanchakvaranont
Putipong Bookkamana
Manee Pinyopornpanish
Kamonporn Wannarit
Sirina Satthapisit
Daochompu Nakawiro
Thanita Hiranyatheb
Kulvadee Thongpibul
author_sort Tinakon Wongpakaran
title Depression and pain: Testing of serial multiple mediators
title_short Depression and pain: Testing of serial multiple mediators
title_full Depression and pain: Testing of serial multiple mediators
title_fullStr Depression and pain: Testing of serial multiple mediators
title_full_unstemmed Depression and pain: Testing of serial multiple mediators
title_sort depression and pain: testing of serial multiple mediators
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983537488&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56094
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