Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection
© 2016 Elsevier B.V. and International Society of Chemotherapy This study aimed to describe the pharmacokinetic (PK) characteristics of meropenem in children with severe infections and to assess the pharmacokinetic/pharmacodynamic (PK/PD) profiles of various meropenem dosage regimens in these patien...
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th-cmuir.6653943832-560982018-09-05T03:08:53Z Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection Kritsana Kongthavonsakul Aroonrut Lucksiri Suntara Eakanunkul Somjing Roongjang Satja Issaranggoon na Ayuthaya Peninnah Oberdorfer Medicine © 2016 Elsevier B.V. and International Society of Chemotherapy This study aimed to describe the pharmacokinetic (PK) characteristics of meropenem in children with severe infections and to assess the pharmacokinetic/pharmacodynamic (PK/PD) profiles of various meropenem dosage regimens in these patients. Fourteen children with severe infections received intravenous (i.v.) bolus doses of meropenem (20 mg/kg/dose) every 8 h (q8h). Serum samples were obtained before and serially after the second dose of meropenem, and a population PK analysis was performed. The final model was used to simulate serum concentration–time profiles with various dosage regimens. The PK/PD target was to achieve a serum meropenem concentration higher than the minimum inhibitory concentration (MIC) of the causative organism (i.e. Pseudomonas aeruginosa and Enterobacteriaceae) for ≥40% of the dosing interval (40%T>MIC). The median age and weight of the children were 6.0 years and 20.0 kg, respectively. Meropenem serum concentration–time profiles were best described by a two-compartmental model with first-order elimination. The simulations showed that the probabilities of target attainment (PTAs) for organisms with an MIC of 1 mg/L were 0.678 and 1.000 following i.v. bolus and 3-h infusion of meropenem (20 mg/kg/dose), respectively. Using a 3-h infusion of a 20 mg/kg/dose, the PTA was 0.999 and 0.765 for organisms with MICs of 4 mg/L and 8 mg/L, respectively. Meropenem given as i.v. bolus doses of 20 mg/kg/dose q8h appeared to be inadequate for PK/PD target attainment for organisms with an MIC of 1 mg/L. The simulations showed that meropenem administration via a 3-h infusion using the same dose improved the PTA. 2018-09-05T03:08:53Z 2018-09-05T03:08:53Z 2016-08-01 Journal 18727913 09248579 2-s2.0-84979680829 10.1016/j.ijantimicag.2016.04.025 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979680829&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56098 |
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Medicine Kritsana Kongthavonsakul Aroonrut Lucksiri Suntara Eakanunkul Somjing Roongjang Satja Issaranggoon na Ayuthaya Peninnah Oberdorfer Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
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© 2016 Elsevier B.V. and International Society of Chemotherapy This study aimed to describe the pharmacokinetic (PK) characteristics of meropenem in children with severe infections and to assess the pharmacokinetic/pharmacodynamic (PK/PD) profiles of various meropenem dosage regimens in these patients. Fourteen children with severe infections received intravenous (i.v.) bolus doses of meropenem (20 mg/kg/dose) every 8 h (q8h). Serum samples were obtained before and serially after the second dose of meropenem, and a population PK analysis was performed. The final model was used to simulate serum concentration–time profiles with various dosage regimens. The PK/PD target was to achieve a serum meropenem concentration higher than the minimum inhibitory concentration (MIC) of the causative organism (i.e. Pseudomonas aeruginosa and Enterobacteriaceae) for ≥40% of the dosing interval (40%T>MIC). The median age and weight of the children were 6.0 years and 20.0 kg, respectively. Meropenem serum concentration–time profiles were best described by a two-compartmental model with first-order elimination. The simulations showed that the probabilities of target attainment (PTAs) for organisms with an MIC of 1 mg/L were 0.678 and 1.000 following i.v. bolus and 3-h infusion of meropenem (20 mg/kg/dose), respectively. Using a 3-h infusion of a 20 mg/kg/dose, the PTA was 0.999 and 0.765 for organisms with MICs of 4 mg/L and 8 mg/L, respectively. Meropenem given as i.v. bolus doses of 20 mg/kg/dose q8h appeared to be inadequate for PK/PD target attainment for organisms with an MIC of 1 mg/L. The simulations showed that meropenem administration via a 3-h infusion using the same dose improved the PTA. |
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Journal |
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Kritsana Kongthavonsakul Aroonrut Lucksiri Suntara Eakanunkul Somjing Roongjang Satja Issaranggoon na Ayuthaya Peninnah Oberdorfer |
author_facet |
Kritsana Kongthavonsakul Aroonrut Lucksiri Suntara Eakanunkul Somjing Roongjang Satja Issaranggoon na Ayuthaya Peninnah Oberdorfer |
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Kritsana Kongthavonsakul |
title |
Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
title_short |
Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
title_full |
Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
title_fullStr |
Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
title_full_unstemmed |
Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
title_sort |
pharmacokinetics and pharmacodynamics of meropenem in children with severe infection |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979680829&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56098 |
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