Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging

© Europa Digital & Publishing 2016. All rights reserved. Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Method...

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Main Authors: Pannipa Suwannasom, Yoshinobu Onuma, Edouard Benit, Olivier Gach, Clemens Von Birgelen, Sjoerd H. Hofma, Yohei Sotomi, Xu Bo, Yao Jun Zhang, Runlin Gao, Hector M. García-García, Joanna J. Wykrzykowska, Robbert J. De Winter, Patrick W. Serruys
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/56105
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spelling th-cmuir.6653943832-561052018-09-05T03:09:00Z Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging Pannipa Suwannasom Yoshinobu Onuma Edouard Benit Olivier Gach Clemens Von Birgelen Sjoerd H. Hofma Yohei Sotomi Xu Bo Yao Jun Zhang Runlin Gao Hector M. García-García Joanna J. Wykrzykowska Robbert J. De Winter Patrick W. Serruys Medicine © Europa Digital & Publishing 2016. All rights reserved. Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were scheduled for OCT examination at six months. The HS was calculated at two time points. Serial OCT imaging demonstrated that the proportion of covered stent struts increased from a median of 87.1% at three months to 98.6% at six months (p<0.001). The neointimal thickness increased from a median of 82.8 μm to 112.2 μm (p<0.001), whereas the median percentages of malapposed struts were 0.2% and 0.0% at the two respective time points. Neointimal volume obstruction increased from 6.3% to 12.8%, and the HS decreased from a median of 28.1 at three months to 2.4 at six months. Conclusions: In patients who had inadequate vascular healing three months after polymer-free SES implantation, serial OCT showed almost complete vascular healing at six months. (ClinicalTrials.gov Identifier: NCT01925027) 2018-09-05T03:09:00Z 2018-09-05T03:09:00Z 2016-08-01 Journal 19696213 1774024X 2-s2.0-84983784767 10.4244/EIJV12I5A97 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983784767&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56105
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Pannipa Suwannasom
Yoshinobu Onuma
Edouard Benit
Olivier Gach
Clemens Von Birgelen
Sjoerd H. Hofma
Yohei Sotomi
Xu Bo
Yao Jun Zhang
Runlin Gao
Hector M. García-García
Joanna J. Wykrzykowska
Robbert J. De Winter
Patrick W. Serruys
Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
description © Europa Digital & Publishing 2016. All rights reserved. Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were scheduled for OCT examination at six months. The HS was calculated at two time points. Serial OCT imaging demonstrated that the proportion of covered stent struts increased from a median of 87.1% at three months to 98.6% at six months (p<0.001). The neointimal thickness increased from a median of 82.8 μm to 112.2 μm (p<0.001), whereas the median percentages of malapposed struts were 0.2% and 0.0% at the two respective time points. Neointimal volume obstruction increased from 6.3% to 12.8%, and the HS decreased from a median of 28.1 at three months to 2.4 at six months. Conclusions: In patients who had inadequate vascular healing three months after polymer-free SES implantation, serial OCT showed almost complete vascular healing at six months. (ClinicalTrials.gov Identifier: NCT01925027)
format Journal
author Pannipa Suwannasom
Yoshinobu Onuma
Edouard Benit
Olivier Gach
Clemens Von Birgelen
Sjoerd H. Hofma
Yohei Sotomi
Xu Bo
Yao Jun Zhang
Runlin Gao
Hector M. García-García
Joanna J. Wykrzykowska
Robbert J. De Winter
Patrick W. Serruys
author_facet Pannipa Suwannasom
Yoshinobu Onuma
Edouard Benit
Olivier Gach
Clemens Von Birgelen
Sjoerd H. Hofma
Yohei Sotomi
Xu Bo
Yao Jun Zhang
Runlin Gao
Hector M. García-García
Joanna J. Wykrzykowska
Robbert J. De Winter
Patrick W. Serruys
author_sort Pannipa Suwannasom
title Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
title_short Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
title_full Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
title_fullStr Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
title_full_unstemmed Evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: A serial follow-up at three and six months with optical coherence tomography imaging
title_sort evaluation of vascular healing of polymer-free sirolimuseluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983784767&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56105
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