Antibiotic resistance of Campylobacter jejuni and C. coli isolated from children with diarrhea in Thailand and Japan

• Main Authors: Ngan Thi Kim Pham, Aksara Thongprachum, Dinh Nguyen Tran, Shuichi Nishimura, Yuko Shimizu-Onda, Quang Duy Trinh, Pattara Khamrin, Nuthapong Ukarapol, Tipachan Kongsricharoern, Shihoko Komine-Aizawa, Shoko Okitsu, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84955079464&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56198
• Institution: Chiang Mai University

© 2016, National Institute of Health. All rights reserved. A total of 29 Campylobacter jejuni and C. coli strains were isolated from Thai and Japanese children with diarrhea using the Loop-mediated Isothermal Amplification method. The samples were evaluated for mutations in gyrA and 23S rRNA in order to assess resistance against fluoroquinolones and macrolides, respectively. Among the isolated strains, 9 (8 C. jejuni and 1 C. coli) were from Thai children, and the other 20 (C. jejuni) were isolated from Japanese children. High fluoroquinolone resistance rates were observed in Thai (66.7%) and Japanese (90%) children. Macrolide resistance was not observed in Japanese children but was observed at a considerable rate of 12.5% of C. jejuni isolated in the Thai cohort. The results indicate that continuous monitoring of resistance of Campylobacter strains to fluoroquinolones and macrolides is definitely necessary.