Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates

© 2016 by Nova Science Publishers, Inc. All rights reserved. Changes in pubertal timing increase risks for adverse health outcomes. Many environmental toxicants have been shown to modulate onset of puberty. Heavy metals (HMs) have been associated with both delayed and precocious puberty but informat...

Full description

Saved in:
Bibliographic Details
Main Authors: Grant A. Walter, Parinya Panuwet, Tippawan Prapamontol, Warangkana Naksen, P. Barry Ryan, Anne Riederer, Dana B. Barr
Format: Book
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029959259&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56230
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-56230
record_format dspace
spelling th-cmuir.6653943832-562302018-09-05T03:11:08Z Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates Grant A. Walter Parinya Panuwet Tippawan Prapamontol Warangkana Naksen P. Barry Ryan Anne Riederer Dana B. Barr Medicine © 2016 by Nova Science Publishers, Inc. All rights reserved. Changes in pubertal timing increase risks for adverse health outcomes. Many environmental toxicants have been shown to modulate onset of puberty. Heavy metals (HMs) have been associated with both delayed and precocious puberty but information is lacking for each HM’s mode of action (MOA). The Hypothalamic-Pituitary-Gonadal (HPG) axis controls pubertal development through release of LH initiated during fetal development. HMs hypothesized MOA for pubertal delay is modulation of HPG axis’ hormone concentration but evidence of this during fetal life is lacking. To examine this hypothesis, we used archived samples collected from 56 mother-infant dyads who participated in the Study of Asian Women and their offSpring’s Development and Environmental Exposures (SAWASDEE) cohort in Chiang Mai, Thailand. Maternal and umbilical cord blood metal concentrations were measured using ICP-MS and neonatal urine luteinizing hormone (LH) concentrations were measured using an enzyme immunoassay. Multiple logistic regression analyses were used to evaluate the relationship between maternal HM levels and neonatal LH categories (<0.4 mlU/mL and = 0.4 mlU/mL). None of the metals tested were associated with LH categories although neonate sex was significantly associated with LH category [OR 11.53 (1.12 - 118.94), p = 0.04]. This is the first study to evaluate prenatal HM exposure in relation to infant LH hormone levels. HM exposures in this small pilot cohort do not appear to be related to LH levels. 2018-09-05T03:11:08Z 2018-09-05T03:11:08Z 2016-01-01 Book 2-s2.0-85029959259 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029959259&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56230
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Grant A. Walter
Parinya Panuwet
Tippawan Prapamontol
Warangkana Naksen
P. Barry Ryan
Anne Riederer
Dana B. Barr
Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
description © 2016 by Nova Science Publishers, Inc. All rights reserved. Changes in pubertal timing increase risks for adverse health outcomes. Many environmental toxicants have been shown to modulate onset of puberty. Heavy metals (HMs) have been associated with both delayed and precocious puberty but information is lacking for each HM’s mode of action (MOA). The Hypothalamic-Pituitary-Gonadal (HPG) axis controls pubertal development through release of LH initiated during fetal development. HMs hypothesized MOA for pubertal delay is modulation of HPG axis’ hormone concentration but evidence of this during fetal life is lacking. To examine this hypothesis, we used archived samples collected from 56 mother-infant dyads who participated in the Study of Asian Women and their offSpring’s Development and Environmental Exposures (SAWASDEE) cohort in Chiang Mai, Thailand. Maternal and umbilical cord blood metal concentrations were measured using ICP-MS and neonatal urine luteinizing hormone (LH) concentrations were measured using an enzyme immunoassay. Multiple logistic regression analyses were used to evaluate the relationship between maternal HM levels and neonatal LH categories (<0.4 mlU/mL and = 0.4 mlU/mL). None of the metals tested were associated with LH categories although neonate sex was significantly associated with LH category [OR 11.53 (1.12 - 118.94), p = 0.04]. This is the first study to evaluate prenatal HM exposure in relation to infant LH hormone levels. HM exposures in this small pilot cohort do not appear to be related to LH levels.
format Book
author Grant A. Walter
Parinya Panuwet
Tippawan Prapamontol
Warangkana Naksen
P. Barry Ryan
Anne Riederer
Dana B. Barr
author_facet Grant A. Walter
Parinya Panuwet
Tippawan Prapamontol
Warangkana Naksen
P. Barry Ryan
Anne Riederer
Dana B. Barr
author_sort Grant A. Walter
title Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
title_short Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
title_full Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
title_fullStr Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
title_full_unstemmed Thai mothers working in agriculture: Effects of heavy metal exposure on endocrine-related hormones in their neonates
title_sort thai mothers working in agriculture: effects of heavy metal exposure on endocrine-related hormones in their neonates
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029959259&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56230
_version_ 1681424653077184512