Recent approaches to evaluating and monitoring geographic atrophy

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review: Given the increasing prevalence of geographic atrophy from age-related macular degeneration as the number of individuals over 85 increases throughout the world, as well as the recent increase in potential treatments...

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Main Authors: Voraporn Chaikitmongkol, Mongkol Tadarati, Neil M. Bressler
Format: Journal
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84957837621&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56238
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-562382018-09-05T03:11:15Z Recent approaches to evaluating and monitoring geographic atrophy Voraporn Chaikitmongkol Mongkol Tadarati Neil M. Bressler Medicine Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review: Given the increasing prevalence of geographic atrophy from age-related macular degeneration as the number of individuals over 85 increases throughout the world, as well as the recent increase in potential treatments to slow growth of geographic atrophy, this article discusses recent findings regarding retinal imaging of geographic atrophy to detect its presence or expansion over time. Recent findings During the review period, the COMPLETE (Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration) and the GATE (Randomized trial to evaluate tandospirone in geographic atrophy secondary to age-related macular degeneration) studies, respectively, reported no beneficial effects of intravenous eculizumab or tandospirone eye drops, respectively, identified on the growth of geographic atrophy. Several imaging and visual function studies have evaluated the role of various techniques using fundus autofluorescence, optical coherence tomography, microperimetry, or other investigator-initiated tools to assess geographic atrophy growth or progression over time, although the ideal imaging for geographic atrophy remains unknown. Some predictive factors for geographic atrophy growth recently suggested include genetic features, geographic atrophy characteristics in the fellow eye, or the presence of outer retinal tubulation on optical coherence tomography. Summary Quantification of geographic atrophy is important for evaluating growth of geographic atrophy. Numerous new imaging techniques of geographic atrophy beyond human grading of fundus photographs or fluorescein angiograms have emerged, but the ideal imaging for geographic atrophy has yet to be determined. 2018-09-05T03:11:15Z 2018-09-05T03:11:15Z 2016-01-01 Journal 15317021 10408738 2-s2.0-84957837621 10.1097/ICU.0000000000000259 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84957837621&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56238
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Voraporn Chaikitmongkol
Mongkol Tadarati
Neil M. Bressler
Recent approaches to evaluating and monitoring geographic atrophy
description Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Purpose of review: Given the increasing prevalence of geographic atrophy from age-related macular degeneration as the number of individuals over 85 increases throughout the world, as well as the recent increase in potential treatments to slow growth of geographic atrophy, this article discusses recent findings regarding retinal imaging of geographic atrophy to detect its presence or expansion over time. Recent findings During the review period, the COMPLETE (Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration) and the GATE (Randomized trial to evaluate tandospirone in geographic atrophy secondary to age-related macular degeneration) studies, respectively, reported no beneficial effects of intravenous eculizumab or tandospirone eye drops, respectively, identified on the growth of geographic atrophy. Several imaging and visual function studies have evaluated the role of various techniques using fundus autofluorescence, optical coherence tomography, microperimetry, or other investigator-initiated tools to assess geographic atrophy growth or progression over time, although the ideal imaging for geographic atrophy remains unknown. Some predictive factors for geographic atrophy growth recently suggested include genetic features, geographic atrophy characteristics in the fellow eye, or the presence of outer retinal tubulation on optical coherence tomography. Summary Quantification of geographic atrophy is important for evaluating growth of geographic atrophy. Numerous new imaging techniques of geographic atrophy beyond human grading of fundus photographs or fluorescein angiograms have emerged, but the ideal imaging for geographic atrophy has yet to be determined.
format Journal
author Voraporn Chaikitmongkol
Mongkol Tadarati
Neil M. Bressler
author_facet Voraporn Chaikitmongkol
Mongkol Tadarati
Neil M. Bressler
author_sort Voraporn Chaikitmongkol
title Recent approaches to evaluating and monitoring geographic atrophy
title_short Recent approaches to evaluating and monitoring geographic atrophy
title_full Recent approaches to evaluating and monitoring geographic atrophy
title_fullStr Recent approaches to evaluating and monitoring geographic atrophy
title_full_unstemmed Recent approaches to evaluating and monitoring geographic atrophy
title_sort recent approaches to evaluating and monitoring geographic atrophy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84957837621&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56238
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