Effect of aromatic substitution of curcumin nanoformulations on their stability
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Curcumin, a poorly water-soluble bioactive compound, was successfully loaded into three different aromatic contents of hydroxypropylmethacrylamide (HPMA)-based polymeric micelles in order to develop water-soluble curcumin nanoformulations (Cu...
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th-cmuir.6653943832-562722018-09-05T03:12:00Z Effect of aromatic substitution of curcumin nanoformulations on their stability Siriporn Okonogi Ornchuma Naksuriya Suporn Charumanee Jakkapan Sirithunyalug Pharmacology, Toxicology and Pharmaceutics © 2016 by the authors; licensee MDPI, Basel, Switzerland. Curcumin, a poorly water-soluble bioactive compound, was successfully loaded into three different aromatic contents of hydroxypropylmethacrylamide (HPMA)-based polymeric micelles in order to develop water-soluble curcumin nanoformulations (Cur-Nano). The stability study of Cur-Nano was done by keeping the formulations at 4, 30, and 40 °C for 90 days. The physical appearance, curcumin remaining, and particle size of Cur-Nano were examined by visual inspection, high-performance liquid chromatography, and dynamic light scattering, respectively. After the storage period, the Cur-Nano composed of 100% aromatic-substituted polymer exhibited the highest stability of curcumin (80% of curcumin remaining) with a similar particle size as measured on the first day (50–60 nm) in all storage conditions. Curcumin in Cur-Nano composed of 25% and 0% aromatic-substituted polymer was significantly less stable accordingly. The results suggested that aromatic substitution to HPMA-based polymeric micelles can significantly enhance the stability of the loaded curcumin, considerably due to the π-π stacking interactions between the aromatic groups of curcumin and the polymer. It is concluded that curcumin-loaded polymeric micelles with high substituted aromatic content can be promising candidates with good storage stability for further clinical evaluations. 2018-09-05T03:12:00Z 2018-09-05T03:12:00Z 2016-12-01 Journal 22180532 00368709 2-s2.0-84995436892 10.3390/scipharm84040625 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995436892&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56272 |
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Pharmacology, Toxicology and Pharmaceutics Siriporn Okonogi Ornchuma Naksuriya Suporn Charumanee Jakkapan Sirithunyalug Effect of aromatic substitution of curcumin nanoformulations on their stability |
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© 2016 by the authors; licensee MDPI, Basel, Switzerland. Curcumin, a poorly water-soluble bioactive compound, was successfully loaded into three different aromatic contents of hydroxypropylmethacrylamide (HPMA)-based polymeric micelles in order to develop water-soluble curcumin nanoformulations (Cur-Nano). The stability study of Cur-Nano was done by keeping the formulations at 4, 30, and 40 °C for 90 days. The physical appearance, curcumin remaining, and particle size of Cur-Nano were examined by visual inspection, high-performance liquid chromatography, and dynamic light scattering, respectively. After the storage period, the Cur-Nano composed of 100% aromatic-substituted polymer exhibited the highest stability of curcumin (80% of curcumin remaining) with a similar particle size as measured on the first day (50–60 nm) in all storage conditions. Curcumin in Cur-Nano composed of 25% and 0% aromatic-substituted polymer was significantly less stable accordingly. The results suggested that aromatic substitution to HPMA-based polymeric micelles can significantly enhance the stability of the loaded curcumin, considerably due to the π-π stacking interactions between the aromatic groups of curcumin and the polymer. It is concluded that curcumin-loaded polymeric micelles with high substituted aromatic content can be promising candidates with good storage stability for further clinical evaluations. |
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Journal |
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Siriporn Okonogi Ornchuma Naksuriya Suporn Charumanee Jakkapan Sirithunyalug |
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Siriporn Okonogi Ornchuma Naksuriya Suporn Charumanee Jakkapan Sirithunyalug |
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Siriporn Okonogi |
title |
Effect of aromatic substitution of curcumin nanoformulations on their stability |
title_short |
Effect of aromatic substitution of curcumin nanoformulations on their stability |
title_full |
Effect of aromatic substitution of curcumin nanoformulations on their stability |
title_fullStr |
Effect of aromatic substitution of curcumin nanoformulations on their stability |
title_full_unstemmed |
Effect of aromatic substitution of curcumin nanoformulations on their stability |
title_sort |
effect of aromatic substitution of curcumin nanoformulations on their stability |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995436892&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56272 |
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