Bioresorbable drug-eluting scaffolds for treatment of vascular disease
© 2016 Informa UK Limited. Introduction: Theoretical advantages of fully bioresorbable scaffold (BRS) stem from transient vessel support without rigid caging. Therefore, it could reduce long-term adverse events associated with the presence of foreign materials.Areas covered: This article will provid...
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th-cmuir.6653943832-562792018-09-05T03:12:16Z Bioresorbable drug-eluting scaffolds for treatment of vascular disease Pannipa Suwannasom Yohei Sotomi Hiroki Tateishi Erhan Tenekecioglu Yaping Zeng Robin P. Kraak Joanna J. Wykrzykowska Robbert J. De Winter Patrick W. Serruys Yoshinobu Onuma Pharmacology, Toxicology and Pharmaceutics © 2016 Informa UK Limited. Introduction: Theoretical advantages of fully bioresorbable scaffold (BRS) stem from transient vessel support without rigid caging. Therefore, it could reduce long-term adverse events associated with the presence of foreign materials.Areas covered: This article will provide an overview of: drug-eluting BRS for various applications in the treatment of vascular disease; The mechanisms of active agent release from such scaffolds; currently available drug-eluting BRS and their future applications are also discussed.Expert opinion: The current BRS have been developed in order to achieve optimal vascular patency while providing long-term safety. The clinical efficacy and safety of BRS in coronary treatment have been reported as equal to that of the current metallic drug eluting stents in simple lesions. The application of BRS can potentially be expanded to other vascular beds. The research in bioengineering for the appropriate materials should not only focus on biocompatibility but also should be tailored according to the sites of implantation, which may require different strength and supporting period. The ultimate goal in this field is to develop a biocompatible device that provides equivalent and complementary therapy to other devices, and is able to disappear when the mechanical support and drug delivery are no longer required. 2018-09-05T03:12:16Z 2018-09-05T03:12:16Z 2016-05-03 Journal 17447593 17425247 2-s2.0-84961205510 10.1517/17425247.2016.1153062 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961205510&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56279 |
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Pharmacology, Toxicology and Pharmaceutics Pannipa Suwannasom Yohei Sotomi Hiroki Tateishi Erhan Tenekecioglu Yaping Zeng Robin P. Kraak Joanna J. Wykrzykowska Robbert J. De Winter Patrick W. Serruys Yoshinobu Onuma Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
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© 2016 Informa UK Limited. Introduction: Theoretical advantages of fully bioresorbable scaffold (BRS) stem from transient vessel support without rigid caging. Therefore, it could reduce long-term adverse events associated with the presence of foreign materials.Areas covered: This article will provide an overview of: drug-eluting BRS for various applications in the treatment of vascular disease; The mechanisms of active agent release from such scaffolds; currently available drug-eluting BRS and their future applications are also discussed.Expert opinion: The current BRS have been developed in order to achieve optimal vascular patency while providing long-term safety. The clinical efficacy and safety of BRS in coronary treatment have been reported as equal to that of the current metallic drug eluting stents in simple lesions. The application of BRS can potentially be expanded to other vascular beds. The research in bioengineering for the appropriate materials should not only focus on biocompatibility but also should be tailored according to the sites of implantation, which may require different strength and supporting period. The ultimate goal in this field is to develop a biocompatible device that provides equivalent and complementary therapy to other devices, and is able to disappear when the mechanical support and drug delivery are no longer required. |
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Journal |
author |
Pannipa Suwannasom Yohei Sotomi Hiroki Tateishi Erhan Tenekecioglu Yaping Zeng Robin P. Kraak Joanna J. Wykrzykowska Robbert J. De Winter Patrick W. Serruys Yoshinobu Onuma |
author_facet |
Pannipa Suwannasom Yohei Sotomi Hiroki Tateishi Erhan Tenekecioglu Yaping Zeng Robin P. Kraak Joanna J. Wykrzykowska Robbert J. De Winter Patrick W. Serruys Yoshinobu Onuma |
author_sort |
Pannipa Suwannasom |
title |
Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
title_short |
Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
title_full |
Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
title_fullStr |
Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
title_full_unstemmed |
Bioresorbable drug-eluting scaffolds for treatment of vascular disease |
title_sort |
bioresorbable drug-eluting scaffolds for treatment of vascular disease |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961205510&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56279 |
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1681424662348693504 |