A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles

© 2015 American Association of Pharmaceutical Scientists. Curcumin, a phenolic compound, possesses many pharmacological activities and is under clinical evaluation to treat different diseases. However, conflicting data about its stability have been reported. In this study, the kinetic degradation of...

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Main Authors: Ornchuma Naksuriya, Mies J. Vansteenbergen, Javier S. Torano, Siriporn Okonogi, Wim E. Hennink
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/56281
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spelling th-cmuir.6653943832-562812018-09-05T03:12:23Z A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles Ornchuma Naksuriya Mies J. Vansteenbergen Javier S. Torano Siriporn Okonogi Wim E. Hennink Pharmacology, Toxicology and Pharmaceutics © 2015 American Association of Pharmaceutical Scientists. Curcumin, a phenolic compound, possesses many pharmacological activities and is under clinical evaluation to treat different diseases. However, conflicting data about its stability have been reported. In this study, the kinetic degradation of curcumin from a natural curcuminoid mixture under various conditions (pH, temperature, and dielectric constant of the medium) was investigated. Moreover, the degradation of pure curcumin at some selected conditions was also determined. To fully solubilize curcumin and to prevent precipitation of curcumin that occurs when low concentrations of co-solvent are present, a 50:50 (v/v) aqueous buffer/methanol mixture was used as standard medium to study its degradation kinetics. The results showed that degradation of curcumin both as pure compound and present in the curcuminoid mixture followed first order kinetic reaction. It was further shown that an increasing pH, temperature, and dielectric constant of the medium resulted in an increase in the degradation rate. Curcumin showed rapid degradation due to autoxidation in aqueous buffer pH=8.0 with a rate constant of 280×10-3h-1, corresponding with a half-life (t1/2) of 2.5 h. Dioxygenated bicyclopentadione was identified as the final degradation product. Importantly, curcumin loaded as curcuminoid mixture in ω-methoxy poly (ethylene glycol)-b-(N-(2-benzoyloxypropyl) methacrylamide) (mPEG-HPMA-Bz) polymeric micelles and in Triton X-100 micelles was about 300-500 times more stable than in aqueous buffer. Therefore, loading of curcumin into polymeric micelles is a promising approach to stabilize this compound and develop formulations suitable for further pharmaceutical and clinical studies. 2018-09-05T03:12:23Z 2018-09-05T03:12:23Z 2016-04-01 Journal 15507416 2-s2.0-85007574899 10.1208/s12248-015-9863-0 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007574899&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56281
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Ornchuma Naksuriya
Mies J. Vansteenbergen
Javier S. Torano
Siriporn Okonogi
Wim E. Hennink
A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
description © 2015 American Association of Pharmaceutical Scientists. Curcumin, a phenolic compound, possesses many pharmacological activities and is under clinical evaluation to treat different diseases. However, conflicting data about its stability have been reported. In this study, the kinetic degradation of curcumin from a natural curcuminoid mixture under various conditions (pH, temperature, and dielectric constant of the medium) was investigated. Moreover, the degradation of pure curcumin at some selected conditions was also determined. To fully solubilize curcumin and to prevent precipitation of curcumin that occurs when low concentrations of co-solvent are present, a 50:50 (v/v) aqueous buffer/methanol mixture was used as standard medium to study its degradation kinetics. The results showed that degradation of curcumin both as pure compound and present in the curcuminoid mixture followed first order kinetic reaction. It was further shown that an increasing pH, temperature, and dielectric constant of the medium resulted in an increase in the degradation rate. Curcumin showed rapid degradation due to autoxidation in aqueous buffer pH=8.0 with a rate constant of 280×10-3h-1, corresponding with a half-life (t1/2) of 2.5 h. Dioxygenated bicyclopentadione was identified as the final degradation product. Importantly, curcumin loaded as curcuminoid mixture in ω-methoxy poly (ethylene glycol)-b-(N-(2-benzoyloxypropyl) methacrylamide) (mPEG-HPMA-Bz) polymeric micelles and in Triton X-100 micelles was about 300-500 times more stable than in aqueous buffer. Therefore, loading of curcumin into polymeric micelles is a promising approach to stabilize this compound and develop formulations suitable for further pharmaceutical and clinical studies.
format Journal
author Ornchuma Naksuriya
Mies J. Vansteenbergen
Javier S. Torano
Siriporn Okonogi
Wim E. Hennink
author_facet Ornchuma Naksuriya
Mies J. Vansteenbergen
Javier S. Torano
Siriporn Okonogi
Wim E. Hennink
author_sort Ornchuma Naksuriya
title A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
title_short A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
title_full A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
title_fullStr A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
title_full_unstemmed A kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
title_sort kinetic degradation study of curcumin in its free form and loaded in polymeric micelles
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007574899&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56281
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