Novel genomic island modifies DNA with 7-deazaguanine derivatives

• Main Authors: Jennifer J. Thiaville, Stefanie M. Kellner, Yifeng Yuan, Geoffrey Hutinet, Patrick C. Thiaville, Watthanachai Jumpathong, Susovan Mohapatra, Celine Brochier-Armanet, Andrey V. Letarov, Roman Hillebrand, Chanchal K. Malik, Carmelo J. Rizzo, Peter C. Dedon, Valérie De Crécy-Lagard
• Format: Journal
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961789525&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56369
• Institution: Chiang Mai University

The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was established b...