β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: β-Cryptoxanthin and astaxanthin are antioxidant carotenoid pigments that inhibit lipid peroxidation as potently as vitamin E. We hypothesized that acute treatment with β-cryptoxanthin and astaxanthin causes similar reductions in the size...

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Main Authors: Wanpitak Pongkan, Osamu Takatori, Yinhua Ni, Liang Xu, Naoto Nagata, Siriporn C. Chattipakorn, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura, Minoru Sugiura, Nipon Chattipakorn, Tsuguhito Ota
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/56444
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spelling th-cmuir.6653943832-564442018-09-05T03:29:08Z β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice Wanpitak Pongkan Osamu Takatori Yinhua Ni Liang Xu Naoto Nagata Siriporn C. Chattipakorn Soichiro Usui Shuichi Kaneko Masayuki Takamura Minoru Sugiura Nipon Chattipakorn Tsuguhito Ota Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: β-Cryptoxanthin and astaxanthin are antioxidant carotenoid pigments that inhibit lipid peroxidation as potently as vitamin E. We hypothesized that acute treatment with β-cryptoxanthin and astaxanthin causes similar reductions in the sizes of cardiac infarcts caused by ischemia-reperfusion (I/R) injury by attenuating oxidative stress and cardiac mitochondrial dysfunction. Methods and results: C57BL/6 mice (n = 36) were randomized to receive vehicle, β-cryptoxanthin, astaxanthin, or vitamin E at 50 mg/kg by gavage feeding prior to I/R injury. Cardiac I/R was induced by left anterior descending coronary artery ligation followed by reperfusion. All treatments significantly reduced infarct sizes by 36–57%, attenuated apoptosis and also attenuated cardiac mitochondrial dysfunction in the treated groups compared to the control group. Although astaxanthin and vitamin E exhibited similar efficacy with respect to cardioprotection, β-cryptoxanthin exhibited greater efficacy than its counterparts, as it reduced infarct sizes by 60%. β-Cryptoxanthin was more effective than astaxanthin and vitamin E because it reduced cardiac mitochondrial swelling, mitochondrial depolarization, the Bax/Bcl-2 ratio, and plasma and cardiac thiobarbituric acid reactive substances levels more significantly than its counterparts. Conclusion: Acute β-cryptoxanthin treatment exhibits greater cardioprotective efficacy against I/R injury than astaxanthin and vitamin E by reducing infarct sizes and attenuating apoptosis, oxidative stress, and mitochondrial dysfunction. 2018-09-05T03:26:25Z 2018-09-05T03:26:25Z 2017-10-01 Journal 16134133 16134125 2-s2.0-85021920920 10.1002/mnfr.201601077 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021920920&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/56444
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
spellingShingle Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Wanpitak Pongkan
Osamu Takatori
Yinhua Ni
Liang Xu
Naoto Nagata
Siriporn C. Chattipakorn
Soichiro Usui
Shuichi Kaneko
Masayuki Takamura
Minoru Sugiura
Nipon Chattipakorn
Tsuguhito Ota
β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
description © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: β-Cryptoxanthin and astaxanthin are antioxidant carotenoid pigments that inhibit lipid peroxidation as potently as vitamin E. We hypothesized that acute treatment with β-cryptoxanthin and astaxanthin causes similar reductions in the sizes of cardiac infarcts caused by ischemia-reperfusion (I/R) injury by attenuating oxidative stress and cardiac mitochondrial dysfunction. Methods and results: C57BL/6 mice (n = 36) were randomized to receive vehicle, β-cryptoxanthin, astaxanthin, or vitamin E at 50 mg/kg by gavage feeding prior to I/R injury. Cardiac I/R was induced by left anterior descending coronary artery ligation followed by reperfusion. All treatments significantly reduced infarct sizes by 36–57%, attenuated apoptosis and also attenuated cardiac mitochondrial dysfunction in the treated groups compared to the control group. Although astaxanthin and vitamin E exhibited similar efficacy with respect to cardioprotection, β-cryptoxanthin exhibited greater efficacy than its counterparts, as it reduced infarct sizes by 60%. β-Cryptoxanthin was more effective than astaxanthin and vitamin E because it reduced cardiac mitochondrial swelling, mitochondrial depolarization, the Bax/Bcl-2 ratio, and plasma and cardiac thiobarbituric acid reactive substances levels more significantly than its counterparts. Conclusion: Acute β-cryptoxanthin treatment exhibits greater cardioprotective efficacy against I/R injury than astaxanthin and vitamin E by reducing infarct sizes and attenuating apoptosis, oxidative stress, and mitochondrial dysfunction.
format Journal
author Wanpitak Pongkan
Osamu Takatori
Yinhua Ni
Liang Xu
Naoto Nagata
Siriporn C. Chattipakorn
Soichiro Usui
Shuichi Kaneko
Masayuki Takamura
Minoru Sugiura
Nipon Chattipakorn
Tsuguhito Ota
author_facet Wanpitak Pongkan
Osamu Takatori
Yinhua Ni
Liang Xu
Naoto Nagata
Siriporn C. Chattipakorn
Soichiro Usui
Shuichi Kaneko
Masayuki Takamura
Minoru Sugiura
Nipon Chattipakorn
Tsuguhito Ota
author_sort Wanpitak Pongkan
title β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
title_short β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
title_full β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
title_fullStr β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
title_full_unstemmed β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
title_sort β-cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021920920&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56444
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