A new ajmaline-type alkaloid from the roots of rauvolfia serpentina

• Main Authors: Thitima Rukachaisirikul, Suwadee Chokchaisiri, Parichat Suebsakwong, Apichart Suksamrarn, Chainarong Tocharus
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019697355&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56594
• Institution: Chiang Mai University

A new ajmaline-type alkaloid, 21-O-methylisoajmaline (1), together with twenty-one known compounds, a mixture of β-sitosterol (2) and stigmasterol (3), reserpinine (4), tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6′-O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3-epi-α-yohimbine (11), methyl 3,4,5-trimethoxy-trans-cinnamate (12), a mixture of β-sitosterol 3-O-β-D-glucopyranoside (13) and stigmasterol 3-O-β-D-glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolfia serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfia and 5, 7, 11, 12, 15, 18 and 22 were found from R. serpentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC50value of 15.58 μM, whereas 6 exhibited strong vasorelaxant activity with the EC50 value of 0.05 μM.