FLT3-ITD, NPM1, and DNMT3A gene mutations and risk factors in normal karyotype acute myeloid leukemia and myelodysplastic syndrome patients in upper Northern Thailand

• Main Authors: Piyanan Mevatee, Adisak Tantiworawit, Patrinee Traisathit, Chaniporn Puaninta, Umnat Mevatee, Sirinda Angsuchawan, Kanokkan Bumroongkit
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85035075730&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/56675
• Institution: Chiang Mai University

Objective: Approximately 40-45% of AML and MDS patients have a cytogenetically normal karyotype (CN-AML and CN-MDS). The frequency and types of gene mutations in these cases may differ among various populations. The objective of this study was to identify frequencies and types of FLT3-ITD, NPM1, and...